Higher Genetic Risk Loads Confer More Diverse Manifestations and Higher Risk of Lupus Nephritis in Systemic Lupus Erythematosus
- Authors
- Kwon, Young-Chang; Ha, Eunji; Kwon, Hyuk-Hee; Park, Dae Jin; Shin, Jung-Min; Joo, Young Bin; Chung, Won Tae; Yoo, Dae-Hyun; Lee, Hye-Soon; Kim, Kwangwoo; Bae, Sang-Cheol; Bang, So-Young
- Issue Date
- Sep-2023
- Publisher
- WILEY
- Citation
- ARTHRITIS & RHEUMATOLOGY, v.75, no.9, pp.1566 - 1572
- Indexed
- SCIE
SCOPUS
- Journal Title
- ARTHRITIS & RHEUMATOLOGY
- Volume
- 75
- Number
- 9
- Start Page
- 1566
- End Page
- 1572
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/191917
- DOI
- 10.1002/art.42516
- ISSN
- 2326-5191
- Abstract
- ObjectiveSystemic lupus erythematosus (SLE) is a highly heritable complex disorder with heterogeneous clinical manifestations. In this study, we aimed to identify the genetic risk load using clinical and serological manifestations in SLE patients. MethodsWe genotyped a total of 1,655 Korean patients with SLE (n = 1,243 as a discovery set and n = 412 as a replication set) using a customized genome-wide single-nucleotide polymorphism (SNP) array, KoreanChip. A weighted genetic risk score (wGRS) for an individual was calculated from 112 well-validated non-HLA SNPs and HLA haplotypes of SLE-risk loci. We analyzed associations between individual wGRS and clinical SLE subphenotypes and autoantibodies using multivariable linear or logistic regression adjusted by onset age, sex, and disease duration. ResultsChildhood-onset SLE (<16 years) conferred the highest genetic risk compared with adult-onset (16-50 years) or late-onset (>50 years) SLE (P = 6.8 x 10(-6)). High wGRS significantly increased associations with SLE manifestations, regardless of onset age, sex, and disease duration. Individual wGRS significantly correlated positively with more clinical American College of Rheumatology criteria (beta = 0.143, P = 1.8 x 10(-6)). Subphenotype analysis revealed significant associations between the highest and lowest wGRS quartile with risk of renal disorder (hazard ratio [HR] 1.74, P = 2.2 x 10(-8)) and anti-Sm antibody production (HR 1.85, P = 2.8 x 10(-5)). Higher wGRS markedly modulated the pathogenesis of proliferative and membranous lupus nephritis class III or IV (HR 1.98, P = 1.6 x 10(-5)) and class V (HR 2.79, P = 1.0 x 10(-3)), but especially lupus nephritis class V in anti-Sm-positive SLE (area under the curve 0.68, P = 1.8 x 10(-4)). ConclusionPatients with SLE and high wGRS tended to have earlier age of SLE onset, higher anti-Sm antibody positivity, and more diverse clinical phenotypes. Genetic profiling may predict high risk for lupus nephritis and a diverse clinical course in SLE patients.
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