Impact of Allergic Disease on the Risk of Mycobacterial Disease
- Authors
- Kim, Taehee; Choi, Hayoung; Lee, Hyun; Han, Kyungdo; Park, Dong Won; Park, Tai Sun; Moon, Ji-Yong; Kim, Tae-Hyung; Sohn, Jang Won; Yoon, Ho Joo; Kim, Sang-Heon
- Issue Date
- Sep-2023
- Publisher
- American Academy of Allergy, Asthma and Immunology
- Keywords
- Allergic rhinitis; Allergy; Asthma; Atopic dermatitis; Mycobacterial disease; Nontuberculosis mycobacterial (NTM) infection; Tuberculosis
- Citation
- Journal of Allergy and Clinical Immunology: In Practice, v.11, no.9, pp.2830 - 2838.e4
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Allergy and Clinical Immunology: In Practice
- Volume
- 11
- Number
- 9
- Start Page
- 2830
- End Page
- 2838.e4
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/192431
- DOI
- 10.1016/j.jaip.2023.04.044
- ISSN
- 2213-2198
- Abstract
- Background: The association between allergic diseases and the risk of mycobacterial disease is unclear. Objective: To evaluate the association between allergic diseases and mycobacterial diseases. Methods: This was a population-based cohort study of 3,838,680 individuals, without prior mycobacterial disease, who participated in the 2009 National Health Screening Exam. We evaluated the prevalence of mycobacterial disease (tuberculosis or nontuberculous mycobacterial infection) in participants with allergic disease (asthma, allergic rhinitis, or atopic dermatitis) and those without allergic disease. We followed the cohort up until the date of mycobacterial disease diagnosis, follow-up loss, death, or December 2018. Results: During a median follow-up of 8.3 (interquartile range, 8.1-8.6) years, 0.6% of participants developed mycobacterial disease. The prevalence of mycobacterial disease was significantly higher in those with allergic diseases than in those without allergic diseases (1.0 vs 0.7/1000 person-years; P < .001), with an adjusted hazard ratio of 1.13 (95% CI, 1.10-1.17). Asthma (adjusted hazard ratio, 1.37; 95% CI, 1.29-1.45) and allergic rhinitis (adjusted hazard ratio, 1.07; 95% CI, 1.04-1.11) increased the hazard of mycobacterial disease, whereas atopic dermatitis did not. The association between allergic diseases and hazard of mycobacterial disease was more prominent in older (age ≥ 65 years, P for interaction = .012) and obese (body mass index ≥ 25 kg/m2, P for interaction < .001) participants. Conclusion: Allergic diseases including asthma and allergic rhinitis were associated with an increased risk of mycobacterial disease, whereas atopic dermatitis was not.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/192431)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.