Properties of Pleural Mesothelial Cells in Idiopathic Pulmonary Fibrosis and Cryptogenic Organizing Pneumoniaopen access
- Authors
- Loloci, Gjustina; Kim, Yu Min; Choi, Won-Il; Jang, Hye Jin; Park, Sang Joon; Kwon, Kun Young
- Issue Date
- Aug-2023
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- CCL18; Idiopathic Pulmonary Fibrosis; LRRN4; Pleural Mesothelial Cell; Uroplakin 3B
- Citation
- Journal of Korean medical science, v.38, no.31, pp.1 - 10
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Journal of Korean medical science
- Volume
- 38
- Number
- 31
- Start Page
- 1
- End Page
- 10
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/192974
- DOI
- 10.3346/jkms.2023.38.e242
- ISSN
- 1011-8934
- Abstract
- BACKGROUND: Profibrotic properties of pleural mesothelial cells may play an important role in the fibrosis activity in idiopathic pulmonary fibrosis (IPF). The purpose of this study was to compare the expression of pleural mesothelial cell markers in IPF and cryptogenic organizing pneumonia (COP), with an assumption that increased expression implies increase in fibrosis. METHODS: Twenty IPF lung samples were stained by immunohistochemistry for the pleural mesothelial cell markers: leucine rich repeat neuronal 4 (LRRN4), uroplakin 3B, CC-chemokine ligand 18, and laminin-5. Nine COP lung samples were used as controls. A semi-quantitative analysis was performed to compare markers expression in IPF and COP. RESULTS: LRRN4 expression was found in epithelial lining cells along the honeycombing and fibroblastic foci in IPF, but not in the fibrotic interstitial lesion and airspace filling fibrous tufts in COP. We found a significant decrease in baseline forced vital capacity when LRRN4 expression was increased in honeycombing epithelial cells and fibroblastic foci. CONCLUSION: LRRN4 expression patterns in IPF are distinct from those in COP. Our findings suggest that mesothelial cell profibrotic property may be an important player in IPF pathogenesis and may be a clue in the irreversibility of fibrosis in IPF.
- Files in This Item
-
- Appears in
Collections - 서울 의과대학 > 서울 교육협력지원교실 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.