Tackling range uncertainty in proton therapy: Development and evaluation of a new multi-slit prompt-gamma camera (MSPGC) system
DC Field | Value | Language |
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dc.contributor.author | Ku, Youngmo | - |
dc.contributor.author | Choi, Sehoon | - |
dc.contributor.author | Cho, Jaeho | - |
dc.contributor.author | Jang, Sehyun | - |
dc.contributor.author | Jeong, Jong Hwi | - |
dc.contributor.author | Kim, Sung Hun | - |
dc.contributor.author | Cho, Sungkoo | - |
dc.contributor.author | Kim, Chan Hyeong | - |
dc.date.accessioned | 2023-11-24T04:56:38Z | - |
dc.date.available | 2023-11-24T04:56:38Z | - |
dc.date.created | 2023-08-07 | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 1738-5733 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/192983 | - |
dc.description.abstract | In theory, the sharp dose falloff at the distal end of a proton beam allows for high conformal dose to the target. However, conformity has not been fully achieved in practice, primarily due to beam range uncertainty, which is approximately 4% and varies slightly across institutions. To address this issue, we developed a new range verification system prototype: a multi-slit prompt-gamma camera (MSPGC). This system features high prompt-gamma detection sensitivity, an advanced range estimation algorithm, and a precise camera positioning system. We evaluated the range measurement precision of the prototype for single spot beams with varying energies, proton quantities, and positions, as well as for spot-scanning proton beams in a simulated SSPT treatment using a phantom. Our results demonstrated high accuracy (<0.4 mm) in range measurement for the tested beam energies and positions. Measurement precision increased significantly with the number of protons, achieving 1% precision with 5 × 108 protons. For spot-scanning proton beams, the prototype ensured more than 5 × 108 protons per spot with a 7 mm or larger spot aggregation, achieving 1% range measurement precision. Based on these findings, we anticipate that the clinical application of the new prototype will reduce range uncertainty (currently approximately 4%) to 1% or less. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Korean Nuclear Society | - |
dc.title | Tackling range uncertainty in proton therapy: Development and evaluation of a new multi-slit prompt-gamma camera (MSPGC) system | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chan Hyeong | - |
dc.identifier.doi | 10.1016/j.net.2023.05.028 | - |
dc.identifier.scopusid | 2-s2.0-85165973412 | - |
dc.identifier.wosid | 001048239700001 | - |
dc.identifier.bibliographicCitation | Nuclear Engineering and Technology, v.55, no.9, pp.3140 - 3149 | - |
dc.relation.isPartOf | Nuclear Engineering and Technology | - |
dc.citation.title | Nuclear Engineering and Technology | - |
dc.citation.volume | 55 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 3140 | - |
dc.citation.endPage | 3149 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002986512 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Nuclear Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nuclear Science & Technology | - |
dc.subject.keywordPlus | CLINICAL-APPLICATION | - |
dc.subject.keywordPlus | KNIFE-EDGE | - |
dc.subject.keywordPlus | VERIFICATION | - |
dc.subject.keywordPlus | OPTIMIZATION | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordAuthor | Multi-slit prompt-gamma camera | - |
dc.subject.keywordAuthor | Proton therapy | - |
dc.subject.keywordAuthor | Range measurement | - |
dc.subject.keywordAuthor | Range uncertainty | - |
dc.subject.keywordAuthor | Range verification | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1738573323002541?via%3Dihub | - |
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