Isosorbide, a versatile green chemical: Elucidating its ADME properties for safe useopen access
- Authors
- Kim, Gi Beom; Seo, Jeong In; Gye, Myung Chan; Yoo, Hye Hyun
- Issue Date
- Mar-2024
- Publisher
- Academic Press
- Keywords
- ADME; GC-MS; Green chemical; Isosorbide
- Citation
- Ecotoxicology and Environmental Safety, v.272, pp 1 - 7
- Pages
- 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- Ecotoxicology and Environmental Safety
- Volume
- 272
- Start Page
- 1
- End Page
- 7
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/194686
- DOI
- 10.1016/j.ecoenv.2024.116051
- ISSN
- 0147-6513
1090-2414
- Abstract
- Isosorbide, an environmentally friendly and renewable substance, finds extensive application in diverse fields, such as a bisphenol A substitute, polymers, functional materials, organic solvents, fuels, and pharmaceuticals. Despite its increasing interest and widespread usage, there remains a notable absence of available reports regarding its absorption, distribution, metabolism, and excretion (ADME) properties. This study endeavors to investigate the ADME characteristics of isosorbide in rats. Isosorbide levels in biological samples were quantified based on the analytical method using gas chromatography-mass spectrometry (GC-MS). Following administration, isosorbide exhibited rapid absorption and elimination, with a bioavailability of 96.1%. The metabolic stability assay indicated that isosorbide remained stable during metabolism. The majority of absorbed isosorbide was promptly excreted, with urinary excretion as the primary route. This study furnishes valuable insights into the ADME of isosorbide, contributing to its safety assessment and fostering its continued application across various domains.
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