Neuron-Specific Enolase as a Predictor of Neurologic Outcomes in Extracorporeal Cardiopulmonary Resuscitation Patients
DC Field | Value | Language |
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dc.contributor.author | Jeong, Yong Ho | - |
dc.contributor.author | Lim, Suk Kyung | - |
dc.contributor.author | Cho, Yongil | - |
dc.contributor.author | Kim, Yun Jin | - |
dc.contributor.author | Jang, Hyo Jun | - |
dc.contributor.author | Cho, Yang Hyun | - |
dc.contributor.author | Shin, Yonghoon | - |
dc.contributor.author | Jung, Jae Seung | - |
dc.contributor.author | Kang, Jin Kook | - |
dc.contributor.author | Cho, Sung-Min | - |
dc.contributor.author | Lee, Jun Ho | - |
dc.date.accessioned | 2024-08-12T02:30:17Z | - |
dc.date.available | 2024-08-12T02:30:17Z | - |
dc.date.issued | 2024-07 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/194969 | - |
dc.description.abstract | Background: Neuron-specific enolase (NSE) has traditionally been used as a biomarker to predict neurologic outcomes after cardiac arrest. This study aimed to evaluate the utility of NSE in predicting neurologic outcomes in patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR). Methods: This observational cohort study included 47 consecutive adult ECPR patients (median age, 59.0 years; 74.5% males) treated between January 2018 and December 2021 at a tertiary extracorporeal life support center. The primary outcome was a poor neurologic outcome, defined as a Cerebral Performance Category score of 3-5 at hospital discharge. Results: Twelve (25.5%) patients had abnormal findings on computed tomography of the brain. A poor neurologic outcome was demonstrated in 22 (46.8%) patients. The NSE level at 72 h after ECPR showed the best prediction power for a poor neurologic outcome compared with NSE at 24 and 48 h. A cutoff value exceeding 61.9 mu g/L for NSE at 72 h yielded an area under the curve (AUC) of 0.791 for predicting poor neurologic outcomes and exceeding 62.1 mu g/L with an AUC of 0.838 for 30-day mortality. Conclusions: NSE levels at 72 h after ECPR appear to be a reliable biomarker for predicting poor neurologic outcomes and 30-day mortality in ECPR patients. | - |
dc.format.extent | 15 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Neuron-Specific Enolase as a Predictor of Neurologic Outcomes in Extracorporeal Cardiopulmonary Resuscitation Patients | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/jcm13144135 | - |
dc.identifier.scopusid | 2-s2.0-85199875175 | - |
dc.identifier.wosid | 001277237500001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, v.13, no.14, pp 1 - 15 | - |
dc.citation.title | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.volume | 13 | - |
dc.citation.number | 14 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 15 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | HOSPITAL CARDIAC-ARREST | - |
dc.subject.keywordPlus | LIFE-SUPPORT | - |
dc.subject.keywordPlus | MEMBRANE-OXYGENATION | - |
dc.subject.keywordPlus | CARDIOGENIC-SHOCK | - |
dc.subject.keywordPlus | ECMO | - |
dc.subject.keywordPlus | COMPLICATIONS | - |
dc.subject.keywordPlus | REPERFUSION | - |
dc.subject.keywordPlus | RELIABILITY | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | SIGNS | - |
dc.subject.keywordAuthor | extracorporeal life support | - |
dc.subject.keywordAuthor | extracorporeal cardiopulmonary resuscitation | - |
dc.subject.keywordAuthor | neuron-specific enolase | - |
dc.subject.keywordAuthor | neurologic outcome | - |
dc.subject.keywordAuthor | mortality | - |
dc.identifier.url | https://www.mdpi.com/2077-0383/13/14/4135 | - |
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