Neuron-Specific Enolase as a Predictor of Neurologic Outcomes in Extracorporeal Cardiopulmonary Resuscitation Patientsopen access
- Authors
- Jeong, Yong Ho; Lim, Suk Kyung; Cho, Yongil; Kim, Yun Jin; Jang, Hyo Jun; Cho, Yang Hyun; Shin, Yonghoon; Jung, Jae Seung; Kang, Jin Kook; Cho, Sung-Min; Lee, Jun Ho
- Issue Date
- Jul-2024
- Publisher
- MDPI
- Keywords
- extracorporeal life support; extracorporeal cardiopulmonary resuscitation; neuron-specific enolase; neurologic outcome; mortality
- Citation
- JOURNAL OF CLINICAL MEDICINE, v.13, no.14, pp 1 - 15
- Pages
- 15
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CLINICAL MEDICINE
- Volume
- 13
- Number
- 14
- Start Page
- 1
- End Page
- 15
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/194969
- DOI
- 10.3390/jcm13144135
- ISSN
- 2077-0383
2077-0383
- Abstract
- Background: Neuron-specific enolase (NSE) has traditionally been used as a biomarker to predict neurologic outcomes after cardiac arrest. This study aimed to evaluate the utility of NSE in predicting neurologic outcomes in patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR). Methods: This observational cohort study included 47 consecutive adult ECPR patients (median age, 59.0 years; 74.5% males) treated between January 2018 and December 2021 at a tertiary extracorporeal life support center. The primary outcome was a poor neurologic outcome, defined as a Cerebral Performance Category score of 3-5 at hospital discharge. Results: Twelve (25.5%) patients had abnormal findings on computed tomography of the brain. A poor neurologic outcome was demonstrated in 22 (46.8%) patients. The NSE level at 72 h after ECPR showed the best prediction power for a poor neurologic outcome compared with NSE at 24 and 48 h. A cutoff value exceeding 61.9 mu g/L for NSE at 72 h yielded an area under the curve (AUC) of 0.791 for predicting poor neurologic outcomes and exceeding 62.1 mu g/L with an AUC of 0.838 for 30-day mortality. Conclusions: NSE levels at 72 h after ECPR appear to be a reliable biomarker for predicting poor neurologic outcomes and 30-day mortality in ECPR patients.
- Files in This Item
-
- Appears in
Collections - 서울 의과대학 > 서울 응급의학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/194969)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.