Fabrication of a novel MOF template-derived ZnCo2O4 composite for the non-enzymatic electrochemical detection of glucose

Abstract

Glucose detection is one of the frequently occurring research due to increased cases of diabetes and the need for continuous monitoring of glucose. MOF template-derived nanocomposites have shown their potential in the field of sensors to address the shortcomings due to selectivity and sensitivity of the present-day sensors. A novel MOF template-derived ZnCo2O4 Composite (ZnCo2O4@MOF) sensing was designed and prepared in this study, and it was employed as an electrochemical sensor for the non-enzymatic detection of glucose with good selectivity and stability. The electrochemical characteristics of the present sensor were evaluated using a cyclic voltammetry (CV), differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS), and amperometry i-t. The template-mediated process and the synergism between the metallic components in the electrocatalyst have provided high electroactive surface area, electrolyte diffusion, and excellent stability that promote electron transfer and enhance the response current. With a wide linear range (0.1 − 100 μM), and 24.8 nM of low detection limit (S/N = 3). The constructed non-enzymatic biosensor exhibited long-term stability and remarkable reproducibility. Furthermore, the ZnCo2O4@MOF composite-modified electrode showed an excellent anti-interference ability against the common molecules that interfere during the detection of glucose.