Hollow hyaluronic acid particles by competition between adhesive and cohesive properties of catechol for anticancer drug carrier
- Authors
- Lee, Jeongwook; Yoo, Ki Chun; Ko, Jaehyoung; Yoo, Bowon; Shin, Joohuei; Lee, Su-Jae; Sohn, Daewon
- Issue Date
- May-2017
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Hyaluronic acid; Catechol; Redox transition; Adhesive; pH triggered release
- Citation
- CARBOHYDRATE POLYMERS, v.164, pp.309 - 316
- Indexed
- SCIE
SCOPUS
- Journal Title
- CARBOHYDRATE POLYMERS
- Volume
- 164
- Start Page
- 309
- End Page
- 316
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/20357
- DOI
- 10.1016/j.carbpol.2017.02.009
- ISSN
- 0144-8617
- Abstract
- The marine mussel-inspired properties of catechol, adhesiveness and cohesiveness, have been applied with pH control to fabricate hollow particles using a silica core and catechol-modified hyaluronic acid (HA-CA) shell for an anticancer drug carrier. The competition between adhesive and cohesive properties of catechol with different pH values leads to various structures, a rough catechol modified HA (HA-CA) shell at pH 5.5, monodisperse spherical silica@HA-CA particles at pH 7.4, and an amorphous HA-CA layer at pH 8.5. The redox transition of catechol with pH is a key factor modulating the behavior of the HA-CA shell on the silica core, which induces strong adhesion of HA-CA to silica at pH 5.5 and structural hardness with cohesive coupling at pH 7.4. In addition, after core removal, the hollow HA-CA particles are followed by loading of anticancer drug, doxorubicin (DOX). DOX loaded HA-CA particles show pH-triggered release behavior and dramatic cytotoxic effect indicating that they are a promising novel anticancer drug carrier.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 자연과학대학 > 서울 화학과 > 1. Journal Articles
- 서울 자연과학대학 > 서울 생명과학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/20357)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.