Comparison of plasma p-tau217 and p-tau181 in predicting amyloid positivity and prognosis among Korean memory clinic patientsopen access
- Authors
- Kwon, Hyuk Sung; Hwang, Mina; Koh, Seong-Ho; Choi, Seong Hye; Lee, Jae-Hong; Kim, Hyung-Ji; Park, So-Hee; Park, Hyun-Hee; Jeong, Jee Hyang; Han, Myung Hoon; Kim, Ji Young
- Issue Date
- Mar-2025
- Publisher
- Nature Publishing Group
- Keywords
- p-tau181; p-tau217; APOE; Amyloid beta; Amyloid positron emission tomography; Alzheimer's disease
- Citation
- Scientific Reports, v.15, no.1, pp 1 - 9
- Pages
- 9
- Indexed
- SCIE
SCOPUS
- Journal Title
- Scientific Reports
- Volume
- 15
- Number
- 1
- Start Page
- 1
- End Page
- 9
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/206942
- DOI
- 10.1038/s41598-025-90232-8
- ISSN
- 2045-2322
2045-2322
- Abstract
- We investigated plasma phosphorylated tau217 (p-tau217) and p-tau181 efficacy in predicting positive amyloid positron emission tomography (PET) results and cognitive stage transitions. Plasma p-tau217 and p-tau181 were measured in participants who were cognitively unimpaired (CU, n = 121), had mild cognitive impairment (n = 102), or dementia (n = 75) from two independent cohorts (Cohort 1: KBASE-V and Cohort 2: Asan) who underwent amyloid PET. In Cohort 1, plasma p-tau217 (area under the curve [AUC] = 0.938, P < 0.001) outperformed p-tau181 (AUC = 0.857, P < 0.001) in predicting amyloid PET positivity (P-difference < 0.001). In Cohort 2, p-tau217 (AUC = 0.893, P < 0.001) and p-tau181 (AUC = 0.856, P < 0.001) showed comparably good discrimination for predicting amyloid PET positivity (P = 0.377). P-tau217 (AUC = 0.852, P < 0.001) and p-tau181 (AUC = 0.828, P < 0.001) demonstrated similarly good discriminations for predicting cognitive stage transition (P-difference = 0.093). Plasma p-tau217 and p-tau181 predicted amyloid PET positivity and cognitive stage transitions well. Plasma p-tau217 might perform better, especially in the early stages.
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Collections - 서울 의과대학 > 서울 신경외과학교실 > 1. Journal Articles
- 서울 의과대학 > 서울 핵의학교실 > 1. Journal Articles
- 서울 의과대학 > 서울 신경과학교실 > 1. Journal Articles

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