Nutraceuticals enhanced by nanotechnology: A new frontier for obesity treatment

Abstract

Nutraceuticals encompass bioactive compounds like polyphenols, flavonoids, and essential fatty acids inherent in food that play defensive roles against human ailments. Presently, the pharmaceutical industry is focused on nutraceutical-based nanomaterials to mitigate drawbacks in obesity treatment. The use of nanomaterials enhances bioavailability, stability, and targeted drug delivery, diminishing side effects. This review delineates the significance, limitations, and molecular mechanisms of nutraceuticals' pharmacological properties, emphasizing how nutraceutical-based nanomaterials address challenges for effective obesity treatment. We outline potential nano-based anti-obesity drugs for heightened pharmacological impact and acknowledge associated clinical challenges and limitations. Critically, we evaluate the advantages and disadvantages of nutraceuticals, advocating various delivery systems to enhance their anti-obesity efficacy. Notably, nutraceutical-based nanoparticles offer increased bioavailability, precise distribution, reduced side effects, and prolonged sustainability, revolutionizing obesity management. Conscious implementation of nutraceutical-based nanoparticles holds promise in alleviating complications associated with conventional nutraceuticals in obesity management.