원발성 갑상선 림프종에 대한 임상적 고찰

Abstract

Background and Objectives: Primary thyroid lymphoma is rare in thyroid cancer and alsoin extranodal lymphoma. As such, there has been only a few studies done on this rare disease,and this study evaluated its clinical characteristics and prognosis. Subjects and Method: A retrospective review was conducted on 18 patients who were treat-ed for primary thyroid lymphoma between January 2006 and December 2021. We investigatedclinical, radiologic, pathologic findings, treatment modalities and prognosis. Results: The study involved 18 patients, all of whom were confirmed through histopathologi-cal assessments via thyroidectomy (5/18), core needle biopsy (12/18), and incisional biopsy(1/18). Among these, three patients were male, while 15 were female, with a mean age of66.4±8.78 (49-82). The most common symptom was a palpable neck mass (8/18). The mostcommon pathologic type was diffuse large B cell lymphoma (9 patients), followed by mucosa-associated lymphoid tissue lymphoma (6 patients). At the time of diagnosis, 3 (20.0%) 8(53.3%), 0, and 4 (26.7%) number of patients were found in Stage I, II, III and IV, respectively. Twelve patients received chemotherapy and three patients received radiation therapy. Threepatients were lost to follow-up without treatment. Conclusion: Primary thyroid lymphoma should be included in differential diagnosis whenmaking a diagnosis for rapid growing thyroid nodule. Core needle biopsy is considered as firstline pathologic diagnostic tool due to limitation of fine needle cytology.