Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Advancements in CRISPR–Cas Systems for Genome Editing towards Eradication of Human Microbial Pathogens
- Authors
- Bhattacharjee, Gargi; Gohil, Nisarg; Khambhati, Khushal; Murjani, Karan; Chu, Dinh Toi; Bui, Nhat Le; Thi, Hue Vu; Mani, Indra; Bansal, Abhisheka; Shamili, Sasanala; Satish, Lakkakula; Ramakrishna, Suresh; Alzahrani, Khalid J.; Singh, Vijai
- Issue Date
- Apr-2026
- Publisher
- SPRINGERNATURE
- Keywords
- CRISPR-Cas systems; Microorganisms; Genome editing; Diagnostic; Therapy
- Citation
- MOLECULAR BIOTECHNOLOGY, v.68, no.4, pp 1718 - 1748
- Pages
- 31
- Indexed
- SCIE
SCOPUS
- Journal Title
- MOLECULAR BIOTECHNOLOGY
- Volume
- 68
- Number
- 4
- Start Page
- 1718
- End Page
- 1748
- ISSN
- 1073-6085
1559-0305
- Abstract
- CRISPR–Cas systems have been explored for targeted genome editing of several organisms. It is rapid, cost-effective, specific, and versatile technology. It requires expression of multidomain single Cas9 protein and single guide RNA (sgRNA) that targets desired nucleic acids in the presence of a protospacer adjacent motif (PAM). This generates a double-stranded break that is repaired by either non-homologous end joining or a homology-directed repair pathway. Currently, several Cas protein variants have been discovered and being used for several biotechnological applications. This review highlights the recent progress of CRISPR–Cas systems for genome editing of mainly human pathogenic microorganisms for their controlling infections.
- Files in This Item
- Go to Link
- Appears in
Collections - 서울 의생명공학전문대학원 > 서울 의생명과학과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Ramakrishna, Suresh
- GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING (DEPARTMENT OF BIOMEDICAL SCIENCE)