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Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer
- Authors
- Kim, Rae-Kwon; Kaushik, Neha; Suh, Yongjoon; Yoo, Ki-Chun; Cui, Yan-Hong; Kim, Min-Jung; Lee, Hae-June; Kim, In-Gyu; Lee, Su-Jae
- Issue Date
- Aug-2016
- Publisher
- IMPACT JOURNALS LLC
- Keywords
- radiation; EMT; Notch signaling; interleukin-6; breast cancer
- Citation
- ONCOTARGET, v.7, no.33, pp.53430 - 53442
- Indexed
- SCIE
SCOPUS
- Journal Title
- ONCOTARGET
- Volume
- 7
- Number
- 33
- Start Page
- 53430
- End Page
- 53442
- Abstract
- Epithelial to mesenchymal transition (EMT) is developmental process associated with cancer metastasis. Here, we found that breast carcinoma cells adopt epithelial-to-mesenchymal transition (EMT) in response to fractionated-radiation. Importantly, we show that Notch signaling is highly activated in fractionally-irradiated tumors as compared to non-irradiated tumors that are accompanied by an EMT. Moreover, we uncovered the mechanism of Notch-driven EMT, in which Notch enhanced EMT through IL-6/JAK/STAT3 signaling axis in mammary tumor cells. Collectively, we present converging evidence from our studies that Notch2 is a critical mediator of radiation-induced EMT and responsible for induced malignant tumor growth.
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