Long-term Prognosis of Anti-Neutrophil Cytoplasmic Antibody-Negative Renal Vasculitis: Cohort Study in Koreaopen access
- Authors
- Lee, Sung Woo; Yu, Mi Yeon; Baek, Seon Ha; Ahn, Shin-Young; Kim, Sejoong; Na, Ki Young; Chae, Dong-Wan; Chin, Ho Jun
- Issue Date
- Apr-2016
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- Anti-Neutrophil Cytoplasmic Antibody (ANCA); Kidney Failure, Chronic; Vasculitis; Mortality; Sex; Proteinuria; Koreans; Prognosis; Survival; Cohort Studies
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.31, no.4, pp.542 - 546
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 31
- Number
- 4
- Start Page
- 542
- End Page
- 546
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/23190
- DOI
- 10.3346/jkms.2016.31.4.542
- ISSN
- 1011-8934
- Abstract
- Few studies have reported on the long-term prognosis of anti-neutrophil cytoplasmic antibody (ANCA)-negative renal vasculitis. Between April 2003 and December 2013, 48 patients were diagnosed with renal vasculitis. Their ANCA status was tested using indirect immunofluorescence and enzyme-linked immunosorbent assays. During a median (interquartile range) follow-up duration of 933.5 (257.5–2,079.0) days, 41.7% of patients progressed to end stage renal disease (ESRD) and 43.8% died from any cause. Of 48 patients, 6 and 42 were ANCA-negative and positive, respectively. The rate of ESRD within 3 months was higher in ANCA-negative patients than in ANCA-positive patients (P = 0.038). In Kaplan-Meier survival analysis, ANCA-negative patients showed shorter renal survival than did ANCA-positive patients (log-rank P = 0.033). In univariate Cox-proportional hazard regression analysis, ANCA-negative patients showed increased risk of ESRD, with a hazard ratio 3.190 (95% confidence interval, 1.028–9.895, P = 0.045). However, the effect of ANCA status on renal survival was not statistically significant in multivariate analysis. Finally, ANCA status did not significantly affect patient survival. In conclusion, long-term patient and renal survival of ANCA-negative renal vasculitis patients did not differ from those of ANCA-positive renal vasculitis patients. Therefore, different treatment strategy depending on ANCA status might be unnecessary.
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