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A multicenter, retrospective analysis of elderly patients with acute myeloid leukemia who were treated with decitabineopen access

Authors
Yi, Jun HoPark, SilviaKim, Jung HanWon, Young-WoongLim, Do HyoungHan, BoramUhm, JieunKim, Hae SuJung, Chul WonJang, Jun Ho
Issue Date
Jan-2018
Publisher
Impact Journals LLC
Keywords
Acute myeloid leukemia; Decitabine; Elderly patients
Citation
Oncotarget, v.9, no.5, pp.6607 - 6614
Indexed
SCOPUS
Journal Title
Oncotarget
Volume
9
Number
5
Start Page
6607
End Page
6614
URI
https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/2427
DOI
10.18632/oncotarget.23823
ISSN
1949-2553
Abstract
Decitabine is widely accepted as the treatment options for elderly acute myeloid leukemia (AML) patients. However, the efficacy has yet been assessed in Asian population. We retrospectively analyzed the outcomes of 80 Korean elderly AML patients who were treated with decitabine. The median age was 74 years (range, 64 to 86 years) and 6 (7.5%), 48 (60.0%), and 25 (31.3%) patients were categorized to favorable, intermediate, and poor risk group, respectively. The median OS was 10.2 months (95% CI 5.0-15.4). Given that decitabine treatment demonstrated improved clinical outcomes, it could be considered as one of the first-line treatment for Korean elderly AML patients. ? Yi et al.
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