Associations between the functional CD40 rs4810485 G/T polymorphism and susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis
- Authors
- Lee, Y. H.; Bae, S-C; Choi, S. J.; Ji, J. D.; Song, G. G.
- Issue Date
- Oct-2015
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- Rheumatoid arthritis; systemic lupus erythematosus; CD40; polymorphism; meta-analysis
- Citation
- LUPUS, v.24, no.11, pp.1177 - 1183
- Indexed
- SCIE
SCOPUS
- Journal Title
- LUPUS
- Volume
- 24
- Number
- 11
- Start Page
- 1177
- End Page
- 1183
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/24836
- DOI
- 10.1177/0961203315583543
- ISSN
- 0961-2033
- Abstract
- Objective
The aim of this study was to determine whether the functional CD40 rs4810485 G/T polymorphism is associated with susceptibility to rheumatoid arthritis (RA) or with susceptibility to systemic lupus erythematosus (SLE).
Methods
A series of meta-analyses were conducted to test for association between the CD40 rs4810485 G/T polymorphism and RA or SLE.
Results
A total of 21 comparisons involving 15,095 patients and 27,050 controls for RA, and 1353 patients and 2342 controls for SLE were considered. Meta-analysis showed a significant association between the CD40 rs4810485 T allele and RA in all subjects (odds ratio (OR) 0.890, 95% confidence interval (CI) 0.846–0.936, p = 5.5 × 10−7). After stratification by ethnicity, the CD40 T allele was found to be significantly associated with RA in Europeans (OR 0.879, 95% CI 0.848–0.901, p = 3.0 × 10−9). A similar pattern of association was observed between the CD40 T allele and RA when the analysis was performed using the recessive, dominant, and additive models. Meta-analysis also showed a significant association between the CD40 polymorphism and SLE in Europeans (OR for the T allele 0.715, 95% CI 0.641–0.832, p = 1.4 × 10−6).
Conclusions
Our meta-analyses confirm that the CD40 rs4810485 G/T polymorphism is associated with susceptibility to RA and SLE in Europeans.
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