Targeting delivery of tocopherol and doxorubicin grafted-chitosan polymeric micelles for cancer therapy: In vitro and in vivo evaluation
- Authors
- Nam, Joung-Pyo; Lee, Kyeong-Jae; Choi, Joung-Woo; Yun, Chae-Ok; Nah, Jae-Woon
- Issue Date
- Sep-2015
- Publisher
- ELSEVIER
- Keywords
- Chitosan; Doxorubicin; pH-sensitive; Targeted delivery
- Citation
- COLLOIDS AND SURFACES B-BIOINTERFACES, v.133, pp.254 - 262
- Indexed
- SCIE
SCOPUS
- Journal Title
- COLLOIDS AND SURFACES B-BIOINTERFACES
- Volume
- 133
- Start Page
- 254
- End Page
- 262
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/24876
- DOI
- 10.1016/j.colsurfb.2015.06.018
- ISSN
- 0927-7765
- Abstract
- In this study, we report the development of a novel, redox-sensitive chitosan-based targeted drug delivery system, containing two drugs. We determined whether the synthesized polymeric micelles (HPTOC-DOX) were suitable as a drug carrier. The formation of HPTOC-DOX micelles was confirmed by H-1 NMR. HPTOC-DOX formed micelles of approximately 151.9 similar to 311.2 nm in size in aqueous solution. Analysis of the drug release profile of HPTOC-DOX in different pH conditions (pH 5.2, 6.2, and 7.4) indicated that DOX was released from HPTOC-DOX micelles at acidic pH (5.2 or 6.2), while almost no DOX was released at pH 7.4. In vitro cell cytotoxicity and hemolysis assays indicated that HPTOC-DOX micelles safely deliver anti-cancer drugs and decrease the cytotoxicity of DOX. In vitro anti-cancer activity assays, confocal laser scanning microscopy analysis of SK-BR-3 cells, and in vivo anti-tumor activity in SK-BR-3-derived tumor-bearing mice were used to evaluate synergistic drug effects and the effect of the targeting peptide (anti-human epidermal growth factor receptor 2 [HER2] target peptide, epitope form; LTVSPWY) on receptor-mediated endocytosis. (C) 2015 Elsevier B.V. All rights reserved.
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