The angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to rheumatoid arthritis, vitiligo and psoriasis: A meta-analysisopen access
- Authors
- Song, Gwan Gyu; Bae, Sang-Cheol; Kim, Jae-Hoon; Lee, Young Ho
- Issue Date
- Mar-2015
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- Angiotensin-converting enzyme; meta-analysis; polymorphism; psoriasis; vitiligo; rheumatoid arthritis
- Citation
- JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, v.16, no.1, pp.195 - 202
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
- Volume
- 16
- Number
- 1
- Start Page
- 195
- End Page
- 202
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/25626
- DOI
- 10.1177/1470320313478285
- ISSN
- 1470-3203
- Abstract
- Introduction:
The purpose of this study was to examine whether the insertion (I) and deletion (D) of angiotensin-converting enzyme (ACE) polymorphism confers susceptibility to psoriasis, vitiligo and rheumatoid arthritis (RA).
Materials and methods:
A meta-analysis was conducted on the association between the ACE I/D polymorphisms and psoriasis, vitiligo and RA.
Results:
Fifteen studies comprising five on psoriasis, five on vitiligo and five on RA were available for the meta-analysis consisting of 2094 cases and 2871 controls. Meta-analysis of the DD+ID genotype showed significant associations with psoriasis (odds ratio (OR) 0.753, 95% confidence interval (CI) 0.601–0.921, p = 0.006). Meta-analysis showed no association between vitiligo and the ACE I/D polymorphism. Meta-analysis of the DD+ID genotype showed an association with RA (OR 2.199, 95% CI 1.379–3.506, p = 0.001). Ethnicity-specific meta-analysis of the D allele showed no association with psoriasis in Europeans, and vitiligo in South Asians. However, subgroup analysis by ethnicity revealed a significant association between the D allele and RA in Arab populations (OR 2.697, 95% CI 1.803–4.034, p = 1.3 × 10−5).
Conclusions:
Our meta-analysis demonstrates that the ACE I/D polymorphism is associated with susceptibility to RA, especially in Arab populations.
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