Association between the CTLA-4, CD226, FAS polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis
- Authors
- Lee, Young Ho; Bae, Sang-Cheol; Song, Gwan Gyu
- Issue Date
- Mar-2015
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Rheumatoid arthritis; CTLA-4; CD226; FAS; Polymorphism
- Citation
- HUMAN IMMUNOLOGY, v.76, no.2-3, pp.83 - 89
- Indexed
- SCIE
SCOPUS
- Journal Title
- HUMAN IMMUNOLOGY
- Volume
- 76
- Number
- 2-3
- Start Page
- 83
- End Page
- 89
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/25629
- DOI
- 10.1016/j.humimm.2015.01.023
- ISSN
- 0198-8859
- Abstract
- Objective
We explored whether cytotoxic T lymphocyte antigen-4 (CTLA-4) rs5742909, CD226 rs763361, FAS rs1800682, and FASL rs763110 polymorphisms are associated with rheumatoid arthritis (RA).
Methods
We performed a meta-analysis on the association between the four gene polymorphisms and RA.
Results
Nineteen studies were included in the meta-analysis. Meta-analysis of all study subjects showed no association between RA and the CTLA-4 rs5742909 T allele (OR = 1.057, 95% CI = 0.782–1.429, p = 0.719). However, the meta-analysis revealed an association between RA and the CD226 rs763361 T allele in all study subjects (OR = 1.294, 95% CI = 1.063–1.576, p = 0.010), and an association was found between the CD226 rs763361 TT genotype and RA in Asians (OR = 1.363, 95% CI = 1.126–1.651, p = 0.001). Meta-analysis showed no association between RA and the FAS rs1800682 G/A polymorphism. However, meta-analysis revealed an association between RA and the FASL rs763110 T allele in all study subjects (OR = 1.366, 95% CI = 1.093–1.707, p = 0.006) and in Asians (OR = 1.402, 95% CI = 1.059–1.855, p = 0.014).
Conclusions
Our meta-analysis demonstrates that the CD226 rs763361 and FASL rs763110 polymorphisms are associated with RA, especially in Asians.
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