Withanone-Rich Combination of Ashwagandha Withanolides Restricts Metastasis and Angiogenesis through hnRNP-K
- Authors
- Gao, Ran; Shah, Navjot; Lee, Jung-Sun; Katiyar, Shashank P.; Li, Ling; Oh, Eonju; Sundar, Durai; Yun, Chae-Ok; Wadhwa, Renu; Kaul, Sunil C.
- Issue Date
- Dec-2014
- Publisher
- AMER ASSOC CANCER RESEARCH
- Citation
- MOLECULAR CANCER THERAPEUTICS, v.13, no.12, pp.2930 - 2940
- Indexed
- SCIE
SCOPUS
- Journal Title
- MOLECULAR CANCER THERAPEUTICS
- Volume
- 13
- Number
- 12
- Start Page
- 2930
- End Page
- 2940
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/25704
- DOI
- 10.1158/1535-7163.MCT-14-0324
- ISSN
- 1535-7163
- Abstract
- Ashwagandha is an important herb used in the Indian system of traditional home medicine, Ayurveda. Alcoholic extract (i-Extract) from its leaves and its component, withanone, were previously shown to possess anticancer activity. In the present study, we developed a combination of withanone and withaferin A, major withanolides in the i-Extract, that retained the selective cancer cell killing activity and found that it also has significant antimigratory, -invasive, and -angiogenic activities, in both in vitro and in vivo assays. Using bioinformatics and biochemical approaches, we demonstrate that these phytochemicals caused downregulation of migration-promoting proteins hnRNP-K, VEGF, and metalloproteases and hence are candidate natural drugs for metastatic cancer therapy. (C)2014 AACR.
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