Associations between Hashimoto Thyroiditis and Clinical Outcomes of Papillary Thyroid Cancer: A Meta-Analysis of Observational Studiesopen access
- Authors
- Moon, Shinje; Chung, Hye Soo; Yu, Jae Myung; Yoo, Hyung Joon; Park, Jung Hwan; Kim, Dong Sun; Park, Young Joo
- Issue Date
- Dec-2018
- Publisher
- KOREAN ENDOCRINE SOC
- Keywords
- Hashimoto disease; Thyroid cancer; papillary; Prognosis
- Citation
- ENDOCRINOLOGY AND METABOLISM, v.33, no.4, pp.473 - 484
- Indexed
- SCOPUS
KCI
- Journal Title
- ENDOCRINOLOGY AND METABOLISM
- Volume
- 33
- Number
- 4
- Start Page
- 473
- End Page
- 484
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/2649
- DOI
- 10.3803/EnM.2018.33.4.473
- ISSN
- 2093-596X
- Abstract
- Background
Epidemiological studies have suggested an association between Hashimoto thyroiditis (HT) and papillary thyroid cancer (PTC) development. Other studies, however, have reported a protective role of HT against PTC progression. Through this updated meta-analysis, we aimed to clarify the effects of HT on the progression of PTC.
Methods
We searched citation databases, including PubMed and Embase, for relevant studies from inception to September 2017. From these studies, we calculated the pooled odds ratios (ORs) of clinicopathologic features and the relative risk (RR) of PTC recurrence with 95% confidence intervals (CIs) using the Mantel-Haenszel method. Additionally, the Higgins I² statistic was used to test for heterogeneity.
Results
The meta-analysis included 71 published studies with 44,034 participants, among whom 11,132 had HT. We observed negative associations between PTC with comorbid HT and extrathyroidal extension (OR, 0.74; 95% CI, 0.68 to 0.81), lymph node metastasis (OR, 0.82; 95% CI, 0.72 to 0.94), distant metastasis (OR, 0.49; 95% CI, 0.32 to 0.76), and recurrence (RR, 0.50; 95% CI, 0.41 to 0.61).
Conclusion
In this meta-analysis, PTC patients with HT appeared to exhibit more favorable clinicopathologic characteristics and a better prognosis than those without HT.
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