Systematic review: agreement between the latent tuberculosis screening tests among patients with rheumatic diseasesopen access
- Authors
- Pyo, Junhee; Cho, Soo-Kyung; Kim, Dam; Sung, Yoon-Kyoung
- Issue Date
- Nov-2018
- Publisher
- KOREAN ASSOC INTERNAL MEDICINE
- Keywords
- Latent tuberculosis; Rheumatic diseases; Interferon-gamma release tests; Tuberculin test; Tumor necrosis factor-alpha
- Citation
- KOREAN JOURNAL OF INTERNAL MEDICINE, v.33, no.6, pp.1241 - 1251
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- KOREAN JOURNAL OF INTERNAL MEDICINE
- Volume
- 33
- Number
- 6
- Start Page
- 1241
- End Page
- 1251
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/2662
- DOI
- 10.3904/kjim.2016.222
- ISSN
- 1226-3303
- Abstract
- Background/Aims
To estimate the level of agreement and positivity rates of latent tuberculosis infection (LTBI) tests prior to the use of tumor necrosis factor (TNF) inhibitors in relation to underlying rheumatic diseases and endemic tuberculosis levels.
Methods
The Ovid-Medline, Embase, and Cochrane Libraries were searched for articles before October 2013 involving LTBI screening in rheumatic patients, including rheumatoid arthritis (RA), ankylosing spondylitis (AS), juvenile idiopathic arthritis (JIA), and psoriatic arthritis.
Results
In pooled analyses, 5,224 rheumatic patients had undergone both a tuberculin skin test (TST) and an interferon-gamma release assay (IGRA) before TNF inhibitors use. The positivity of TST, QuantiFERON-TB Gold In Tube (QFT-GIT), and T-SPOT.TB (T-SPOT) tests were estimated to be 29%, 17%, and 18%, respectively. The agreement percentage between the TST and QFT-GIT, and between the TST and T-SPOT were 73% and 75%. Populations from low-to-moderate endemic TB presented with slightly less agreement (71% between TST and QFT-GIT, and 74% between TST and T-SPOT) than patients from high endemic countries (73% between TST and QFT-GIT, and 81% between TST and T-SPOT). By underlying disease stratification, a lower level of agreement between TST and QFT-GIT was found among AS (64%) than among JIA (77%) and RA patients (73%).
Conclusions
We reaffirm the current evidence for accuracy of LTBI test done by TST and IGRA among rheumatic patients is inconsistent. Our stratified analysis suggests different screening strategies might be needed in clinical settings considering the endemic status in the patient’s country of origin and the precise nature of underlying diseases.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 교육협력지원교실 > 1. Journal Articles
- 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/2662)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.