Poly-γ-glutamic acid suppresses osteoclastogenesis in human osteoclast precursors and prevents joint damage in a collagen-induced murine arthritis modelPoly-gamma-glutamic acid suppresses osteoclastogenesis in human osteoclast precursors and prevents joint damage in a collagen-induced murine arthritis model
- Other Titles
- Poly-gamma-glutamic acid suppresses osteoclastogenesis in human osteoclast precursors and prevents joint damage in a collagen-induced murine arthritis model
- Authors
- Lee, Bitnara; Jo, Sungsin; Kim, Sung-Min; Cho, Mi-La; Park, Sung-Hwan; Youn, Jeehee; Ji, Jong Dae; Kim, Tae-Hwan
- Issue Date
- Nov-2018
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Poly-gamma-glutamic acid (gamma-PGA); Osteoclast; Rheumatoid arthritis
- Citation
- IMMUNOLOGY LETTERS, v.203, pp.80 - 86
- Indexed
- SCIE
SCOPUS
- Journal Title
- IMMUNOLOGY LETTERS
- Volume
- 203
- Start Page
- 80
- End Page
- 86
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/2664
- DOI
- 10.1016/j.imlet.2018.09.004
- ISSN
- 0165-2478
- Abstract
- Poly–γ-glutamic acid (γ-PGA), a natural polymer derived from Bacillus subtilis, shows anti-inflammatory activity. However, the effects of γ-PGA on osteoclasts, which are important cells for joint destruction in inflammatory diseases such as rheumatoid arthritis (RA), have not yet been reported. In this study, we show that γ-PGA markedly inhibits osteoclast differentiation in normal PBMC-derived osteoclast precursors and in synovial fluid macrophages of patients with RA. γ-PGA also reduces RANK expression by down-regulating M-CSF receptors. Additionally, oral administration of γ-PGA attenuated bone destruction in a collagen-induced arthritis (CIA) model, demonstrating decreases in inflammation, cartilage damage, and osteoclast formation in histological analyses. Taken together, these data suggest that γ-PGA could be a good candidate for therapeutic prevention of joint destruction in RA.
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