Antiphospholipid Antibody Positivity and the Clinical Outcomes of Patients with Systemic Lupus Erythematosusopen access
- Authors
- Nam, Seoung Wan; Cho, Soo-Kyung; Kim, Dam; Lee, Kyung-Eun; Park, Dong-Jin; Lee, Shin-Seok; Sung, Yoon-Kyoung
- Issue Date
- Oct-2018
- Publisher
- KOREAN COLL RHEUMATOLOGY
- Keywords
- Antiphospholipid antibody; Systemic lupus erythematosus; Chronic kidney disease
- Citation
- JOURNAL OF RHEUMATIC DISEASES, v.25, no.4, pp.239 - 247
- Indexed
- KCI
- Journal Title
- JOURNAL OF RHEUMATIC DISEASES
- Volume
- 25
- Number
- 4
- Start Page
- 239
- End Page
- 247
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/2669
- DOI
- 10.4078/jrd.2018.25.4.239
- ISSN
- 2093-940X
- Abstract
- Objective
To identify the prevalence of antiphospholipid antibodies (aPL) in systemic lupus erythematosus (SLE) patients and determine the relationship between aPL and the clinical outcomes.
Methods
SLE patients with aPL test results within 2 years of enrollment were selected from Korean lupus network study. They were classified into two groups: aPL (+) group, patients positive for at least one aPL, and aPL (−) group, patients without an aPL. The clinical characteristics of the two groups were compared and the role of aPL in the risk of chronic kidney disease (CKD) in SLE patients was examined.
Results
Among the 469 SLE patients, 69 (14.7%) had at least one aPL. The prevalence of cerebrovascular disease and CKD was higher in the aPL (+) group than in the aPL (−) group (10.1% vs. 1.8% and 13.8% vs. 5.1%, p<0.05). Multivariable regression analysis showed that the aPL positivity (odds ratio=3.93, 95% confidence interval=1.48∼10.47) was associated with the risk of CKD after adjusting for age, disease duration, and lupus nephritis history.
Conclusion
Among the 469 SLE patients, 69 (14.7%) had at least one aPL. The prevalence of cerebrovascular disease and CKD was higher in the aPL (+) group than in the aPL (−) group (10.1% vs. 1.8% and 13.8% vs. 5.1%, p<0.05). Multivariable regression analysis showed that the aPL positivity (odds ratio=3.93, 95% confidence interval=1.48∼10.47) was associated with the risk of CKD after adjusting for age, disease duration, and lupus nephritis history.
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