Copper induces apoptotic cell death through reactive oxygen species-triggered oxidative stress in the intertidal copepod Tigriopus japonicus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rhee, Jae-Sung | - |
dc.contributor.author | Yu, In Tag | - |
dc.contributor.author | Kim, Bo-Mi | - |
dc.contributor.author | Jeong, Chang-Bum | - |
dc.contributor.author | Lee, Kyun-Woo | - |
dc.contributor.author | Kim, Min-Jung | - |
dc.contributor.author | Lee, Su-Jae | - |
dc.contributor.author | Park, Gyung Soo | - |
dc.contributor.author | Lee, Jae-Seong | - |
dc.date.accessioned | 2021-08-02T18:57:14Z | - |
dc.date.available | 2021-08-02T18:57:14Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2013-05 | - |
dc.identifier.issn | 0166-445X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/26741 | - |
dc.description.abstract | The copepod, Tigriopus japonicus is an important model for toxicity testing. However, no attempt has been made in analyzing the effect of toxicants at the level of the ROS-mediated signal transduction pathway. To understand copper-induced cytotoxicity at the molecular level, we employed several cellular and biochemical assays after exposure to copper, and found a significant induction of enzyme activities of antioxidant proteins with increased intracellular reactive oxygen species (ROS) as well as an increase of TUNEL-positive cells, but a decrease of BrdU-positive cells. In addition, several important genes such as p38 MAPK, antioxidant-related genes, Hsps, and apoptosis-related genes were significantly modulated by copper exposure. Taken together, we suggest that copper-induced cytotoxicity is mediated by the formation of intracellular ROS and oxidative stress in T. japonicus. Whole body biochemical assays such as TUNEL- and BrdU-assay will provide a better understanding of cellular responses such as apoptosis and cell death upon cytotoxic exposure of copper in T. japonicus. (C) 2013 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Copper induces apoptotic cell death through reactive oxygen species-triggered oxidative stress in the intertidal copepod Tigriopus japonicus | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Su-Jae | - |
dc.identifier.doi | 10.1016/j.aquatox.2013.02.013 | - |
dc.identifier.scopusid | 2-s2.0-84875598815 | - |
dc.identifier.wosid | 000318387000021 | - |
dc.identifier.bibliographicCitation | AQUATIC TOXICOLOGY, v.132, pp.182 - 189 | - |
dc.relation.isPartOf | AQUATIC TOXICOLOGY | - |
dc.citation.title | AQUATIC TOXICOLOGY | - |
dc.citation.volume | 132 | - |
dc.citation.startPage | 182 | - |
dc.citation.endPage | 189 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Marine & Freshwater Biology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Marine & Freshwater Biology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | SUPEROXIDE-DISMUTASE SOD | - |
dc.subject.keywordPlus | LEUKEMIA HL-60 CELLS | - |
dc.subject.keywordPlus | CYTOCHROME-C | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | CASPASE ACTIVATION | - |
dc.subject.keywordPlus | TRACE-METALS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordAuthor | Tigriopus japonicus | - |
dc.subject.keywordAuthor | Copper | - |
dc.subject.keywordAuthor | Cytotoxicity | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | TUNEL assay | - |
dc.subject.keywordAuthor | BrdU assay | - |
dc.subject.keywordAuthor | p38 MAPK | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.