The Role of Waixenicin A as Transient Receptor Potential Melastatin 7 Blockeropen access
- Authors
- Kim, Byung J.; Nam, Joo H.; Kwon, Young K.; So, Insuk; Kim, Seon J.
- Issue Date
- Feb-2013
- Publisher
- WILEY-BLACKWELL
- Citation
- BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, v.112, no.2, pp.83 - 89
- Indexed
- SCIE
SCOPUS
- Journal Title
- BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Volume
- 112
- Number
- 2
- Start Page
- 83
- End Page
- 89
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/26780
- DOI
- 10.1111/j.1742-7843.2012.00929.x
- ISSN
- 1742-7835
- Abstract
- Transient receptor potential melastatin 7 (TRPM7) plays a role in a number of physiological and pharmacological functions in variety of cells. The aim of this study was to clarify the role for TRPM7 channels and the effect of waixenicin A on the pacemaking activity of interstitial cells of Cajal (ICCs) and on the cell viability of the human gastric and breast adenocarcinoma cell lines, AGS and MCF-7, respectively. Waixenicin A decreased the amplitude of pacemaker potentials in cultured ICC clusters and inhibited TRPM7 currents, but had no effect on Ca2+-activated Cl- conductance (ANO1). Furthermore, waixenicin A was found to inhibit the growth and survival of AGS and MCF-7 cells. These findings indicate that TRPM7 channel modulates intestinal motility and regulates the pathophysiology of human gastric and breast adenocarcinoma cells. These findings suggest that TRPM7 channel be considered a potential target for the treatment of gut motor disorders and gastric and breast cancer.
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