Omega-3 Polyunsaturated Fatty Acids and the Treatment of Rheumatoid Arthritis: A Meta-analysis
- Authors
- Lee, Young-Ho; Bae, Sang-Cheol; Song, Gwan-Gyu
- Issue Date
- Jul-2012
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Omega-3 polyunsaturated fatty acids; Rheumatoid arthritis
- Citation
- ARCHIVES OF MEDICAL RESEARCH, v.43, no.5, pp.356 - 362
- Indexed
- SCIE
SCOPUS
- Journal Title
- ARCHIVES OF MEDICAL RESEARCH
- Volume
- 43
- Number
- 5
- Start Page
- 356
- End Page
- 362
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/27509
- DOI
- 10.1016/j.arcmed.2012.06.011
- ISSN
- 0188-4409
- Abstract
- Background and Aims
We undertook this study to assess the effects of omega-3 polyunsaturated fatty acids (PUFAs) (administered at ≥2.7 g/day) for a minimum duration of 3 months on clinical outcomes in patients with rheumatoid arthritis (RA).
Methods
The authors surveyed randomized controlled trials (RCTs) that examined the effects of omega-3 PUFAs on clinical outcomes in RA patients using Medline and the Cochrane Controlled Trials Register and by performing manual searches. Meta-analysis of RCTs was performed using fixed and random effects models. Outcomes are presented as standardized mean differences (SMD).
Results
Ten RCTs involving 183 RA patients and 187 placebo-treated RA controls were included in this meta-analysis. The analysis showed that omega-3 PUFAs clearly reduced nonsteroidal anti-inflammatory drug (NSAID) consumption (SMD −0.518, 95% CI −0.915 to −0.121, p = 0.011) without between-study heterogeneity (I2 = 0%). Tender joint count (SMD −0.214, 95% CI−0.489–0.062, p = 0.128), swollen joint count (SMD −0.170, 95% CI−0.454–0.114, p = 0.241), morning stiffness (SMD −0.224, 95% CI−0.955–0.212, p = 0.221), and physical function (SMD 0.264, 95% CI−0.232–0.724, p = 0.314) showed a trend to improve more in patients treated with omega-3 PUFAs than in placebo-treated controls, but they did not reach statistical significance.
Conclusions
This meta-analysis suggests that the use of omega-3 PUFAs at dosages >2.7 g/day for >3 months reduces NSAID consumption by RA patients. Further studies are needed to explore the clinical and NSAID-sparing effects of omega-3 PUFAs in RA.
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