Associations between gene polymorphisms and rheumatoid arthritis: a meta-analysis
- Authors
- Lee, Young Ho; Bae, Sang-Cheol; Choi, Sung Jae; Ji, Jong Dae; Song, Gwan Gyu
- Issue Date
- Jun-2012
- Publisher
- SPRINGER BASEL AG
- Keywords
- Tumor necrosis factor alpha inducible protein 3; Polymorphism; Rheumatoid arthritis; Meta-analysis
- Citation
- INFLAMMATION RESEARCH, v.61, no.6, pp.635 - 641
- Indexed
- SCIE
SCOPUS
- Journal Title
- INFLAMMATION RESEARCH
- Volume
- 61
- Number
- 6
- Start Page
- 635
- End Page
- 641
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/27531
- DOI
- 10.1007/s00011-012-0455-5
- ISSN
- 1023-3830
- Abstract
- Objective
The aim of this study was to determine whether tumor necrosis factor alpha inducible protein 3 (TNFAIP3) polymorphisms confer susceptibility to rheumatoid arthritis (RA) in ethnically different populations.
Methods
The authors conducted meta-analyses on associations between the TNFAIP3 polymorphisms and RA susceptibility.
Result
A total of ten comparative studies were included in this meta-analysis, which showed an association between the two allele of rs6920220 and RA in all study subjects [odds ratio (OR) 1.216, 95% confidence interval (CI) 1.166–1.269, p < 1.0 × 10−9]. The two allele of rs6920220 was also significantly associated with RA in Europeans only (OR 1.227, 95% CI 1.175–1.282, p < 1.0 × 10−9). Meta-analysis revealed no association between the two allele of the rs10499194 polymorphism and RA in Europeans, but a significant association was found in Asians (OR 1.254, 95% CI 1.101–1.429, p = 6.7 × 10−4). Furthermore, an association was found between the two allele of rs2230926 and RA in all study subjects (OR 1.390, 95% CI 1.214–2.331, p = 1.9 × 10−6).
Conclusions
This meta-analysis confirms that the TNFAIP3 polymorphisms are associated with RA susceptibility in different ethnic groups, namely, in Europeans for rs6920220 and in Asians for rs10499194.
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