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Cited 6 time in webofscience Cited 5 time in scopus
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Evaluation of disease activity indices in Korean patients with rheumatoid arthritis

Authors
Park, So-YeonLee, HyeseonCho, Soo-KyungChoi, Chan-BumSung, Yoon-KyoungBae, Sang-Cheol
Issue Date
Feb-2012
Publisher
SPRINGER HEIDELBERG
Keywords
Disease activity score; ESR; CRP; Disease activity index; Rheumatoid arthritis
Citation
RHEUMATOLOGY INTERNATIONAL, v.32, no.2, pp.545 - 549
Indexed
SCIE
SCOPUS
Journal Title
RHEUMATOLOGY INTERNATIONAL
Volume
32
Number
2
Start Page
545
End Page
549
URI
https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/27600
DOI
10.1007/s00296-011-1798-x
ISSN
0172-8172
Abstract
The aim of this study is to examine the validity of the rheumatoid arthritis (RA), disease activity score (DAS), 28-C-reactive protein (CRP), the simplified disease activity index (SDAI), and the clinical disease activity index (CDAI) against the DAS28-erythrocyte sedimentation rate (ESR) and determine cut-off values for each tool in Korean patients with RA. A total of 223 RA patients were consecutively recruited from the Hanyang University Hospital for Rheumatic Diseases in Seoul, Korea. DAS28-CRP, SDAI, and CDAI were measured and compared with DAS28-ESR. The correlation coefficients of DAS28-ESR with DAS28-CRP, SDAI, and CDAI were 0.93, 0.85, and 0.84, demonstrating strong linear relationships. The cut-off values of DAS28-CRP classifying RA patients into four categories of disease activity were defined as 2.19, 2.60, and 4.07. SDAI cut-off values were defined as 3.75, 7.50, and 16.88. CDAI cut-off values were defined as 3.62, 7.38, and 16.50. DAS28-CRP, SDAI, and CDAI are valid and sensitive assessment indices of disease activity that are comparable to DAS28-ESR. The cut-off values of each tool derived in this study might be useful for routine monitoring and therapeutic decision-making in Korean RA patients.
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