Mortalin targeting gadgets for cancer therapy
- Authors
- Yun, C.-O.; Wadhwa, R.
- Issue Date
- Apr-2012
- Publisher
- Springer Netherlands
- Subjects
- Mortalin; Targeting Antisense; Ribozyme; siRNA; Oncolytic; adenoviruses; Apoptosis Therapy
- Abstract
- Mortalin, also known as GRP75/mtHSP70/PBP74, is a member of the hsp70 family of proteins. It is frequently enriched in cancers and shows distinct subcellular distribution in normal and immortal/cancer cells. Mortalin-overexpressing immortalized human cells show enhanced malignant properties, including anchorage-independent growth, formation of tumors in nude mice and chemotaxis. Targeting mortalin with antisense, ribozyme or siRNA specific for mortalin induced tumor cell-specific growth arrest and apoptosis suggesting that the development of various modalities for targeting mortalin may be useful in clinical applications. In this chapter, we discuss the various strategies that have been explored to generate mortalin-targeted cancer gene therapeutics.
- Pages
- 342
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/27757
- DOI
- 10.1007/978-94-007-3027-4_18
- Start Page
- 279
- End Page
- 291
- ISBN
- 978-94-007-3026-7
- Files in This Item
- There are no files associated with this item.
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Collections - 서울 공과대학 > 서울 생명공학과 > 3. Books & Book Chapters
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