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Multifunctional Nanoparticles for Targeted Chemophotothermal Treatment of Cancer Cells
- Issue Date
- Aug-2011
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- cancer; chemophotothermal treatment; drug delivery; nanoparticles
- Citation
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.50, no.33, pp.7581 - 7586
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Volume
- 50
- Number
- 33
- Start Page
- 7581
- End Page
- 7586
- ISSN
- 1433-7851
- Abstract
- Drug and heat delivery to tumors by active targeting with Herceptin-conjugated doxorubicin-loaded poly(ethylene glycol)-poly(lactic-co- glycolic acid)-Au half-shell nanoparticles (HER-DOX-PLGA-Au H-S NPs) is more effective than passive targeting with their HER-free counterparts (DOX-PLGA-Au H-S NPs). Thus, on NIR irradiation, higher intratumoral temperatures were reached in tumor-bearing mice that were treated with the HER-conjugated particles (see picture). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Related Researcher
- Yun, Chae Ok
- COLLEGE OF ENGINEERING (DEPARTMENT OF BIOENGINEERING)