Blood and sputum protein biomarkers for chronic obstructive pulmonary disease (COPD)
- Authors
- Moon, Ji-Yong; Leitao Filho, Fernando Sergio; Shahangian, Kimeya; Takiguchi, Hiroto; Sin, Don D.
- Issue Date
- Nov-2018
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- COPD; sputum biomarker; blood biomarker
- Citation
- EXPERT REVIEW OF PROTEOMICS, v.15, no.11, pp.923 - 935
- Indexed
- SCIE
SCOPUS
- Journal Title
- EXPERT REVIEW OF PROTEOMICS
- Volume
- 15
- Number
- 11
- Start Page
- 923
- End Page
- 935
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3007
- DOI
- 10.1080/14789450.2018.1539670
- ISSN
- 1478-9450
- Abstract
- Introduction: Chronic obstructive pulmonary disease (COPD) is a heterogeneous set of disorders, characterized by airflow limitation, and reduced lung function. Despite increasing knowledge regarding its pathophysiology, there has been limited advancement in therapeutics and the current treatment strategy is symptom management and prevention of exacerbations.
Areas covered: Biomarkers represent important tools for the implementation of precision medicine. As fundamental molecules of all living processes, proteins could provide crucial information about how genes interact with the environment. Proteomics studies could act as important tools in identifying reliable biomarkers to enable a more precise therapeutic approach. In this review, we will explore the most promising blood and sputum protein biomarkers in COPD that have been consistently reported in the literature.
Expert commentary: Given the complexity of COPD, no single protein biomarker has been able to improve the outcomes of COPD patients. According to preliminary studies, precision medicine in COPD will likely require a combination of different proteins in a biomarker panel for clinical translation. With advancements in current mass spectrometry techniques, an enhancement in the identification of new biomarkers will be observed, and improvements in sequence database search can fill in potential gaps between biomarker discovery and patient care.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3007)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.