Emission and Cytotoxicity of Surgical Smoke: Cholesta-3,5-Diene Released from Pyrolysis of Prostate Tissueopen access
- Authors
- Bae, Min-Suk; Park, Jong Kwan; Kim, Ki-Hyun; Cho, Seung-Sik; Lee, Kwang-Yul; Shon, Zang-Ho
- Issue Date
- Oct-2018
- Publisher
- MDPI
- Keywords
- organic compounds; surgical aerosol; surgical carbonaceous material; toxicity; surgical smoke
- Citation
- ATMOSPHERE, v.9, no.10, pp.1 - 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- ATMOSPHERE
- Volume
- 9
- Number
- 10
- Start Page
- 1
- End Page
- 7
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3023
- DOI
- 10.3390/atmos9100381
- ISSN
- 2073-4433
- Abstract
- Respiratory and lung irritants can be a by-product of the surgical pyrolysis of human tissues. Seven prostate tissues were collected during the transurethral resection of a prostate (TURP). Tissue samples, pyrolyzed in a pyrolysis sampling system, were collected and analyzed for the characterization of aerosols in the surgical smoke. In the pyrolyzed particulate matter (PM) from the TURP, Cholestra-3,5-diene was identified as the most dominant component along with 9-methylanthracene, hentriacontane, and dotriacontane based on the mass fragment structure determined using gas chromatography-mass spectrometry (GC-MS). As a molecular marker, Cholesta-3,5-diene can be associated with a cytotoxic in primary human oral keratinocytes (HOK). In this research, the presence of Cholestra-3,5-diene is reported for the first time as a by-product of surgical pyrolysis.
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