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Bioactive nano-metal-organic frameworks as antimicrobials against Gram-positive and Gram-negative bacteriaopen access
- Authors
- Bhardwaj, Neha; Pandey, Satish K.; Mehta, Jyotsana; Bhardwaj, Sanjeev K.; Kim, Ki-Hyun; Deep, Akash
- Issue Date
- Sep-2018
- Publisher
- OXFORD UNIV PRESS
- Citation
- TOXICOLOGY RESEARCH, v.7, no.5, pp.931 - 941
- Indexed
- SCIE
SCOPUS
- Journal Title
- TOXICOLOGY RESEARCH
- Volume
- 7
- Number
- 5
- Start Page
- 931
- End Page
- 941
- ISSN
- 2045-452X
- Abstract
- More effective antibiotics are needed to overcome the problem of multidrug resistance. The antibacterial efficacies of three Zn-based nano metal-organic frameworks (nMOFs) - IRMOF-3, MOF-5, and Zn-BTC - were explored, both alone and as mixtures with ampicillin and kanamycin. When tested against Escherichia coli, Staphylococcus aureus, Staphylococcus lentus, and Listeria monocytogenes, the nMOF/drug mixtures demonstrated synergistic (IRMOF-3/kanamycin) or additive (other nMOF/drug combinations) effects compared with the nMOFs or antibiotics alone. Zn-Based nMOFs can reduce the burden of the new discovery of antimicrobial pharmaceuticals by increasing the potency of existing antibiotics.
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Related Researcher
- Kim, Ki Hyun
- COLLEGE OF ENGINEERING (DEPARTMENT OF CIVIL AND ENVIRONMENTAL ENGINEERING)