Coefficient of Variance as Quality Criterion for Evaluation of Advanced Hepatic Fibrosis Using 2D Shear-Wave Elastography
- Authors
- Lim, Sanghyeok; Kim, Seung Hyun; Kim, Yongsoo; Cho, Young Seo; Kim, Tae Yeob; Jeong, Woo Kyoung; Sohn, Joo Hyun
- Issue Date
- Feb-2018
- Publisher
- WILEY
- Keywords
- elastography; hepatic fibrosis; hepatobiliary; liver cirrhosis; sonoelastography
- Citation
- JOURNAL OF ULTRASOUND IN MEDICINE, v.37, no.2, pp.355 - 362
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF ULTRASOUND IN MEDICINE
- Volume
- 37
- Number
- 2
- Start Page
- 355
- End Page
- 362
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3169
- DOI
- 10.1002/jum.14341
- ISSN
- 0278-4297
- Abstract
- Objectives
To compare the diagnostic performance for advanced hepatic fibrosis measured by 2D shear-wave elastography (SWE), using either the coefficient of variance (CV) or the interquartile range divided by the median value (IQR/M) as quality criteria.
Methods
In this retrospective study, from January 2011 to December 2013, 96 patients, who underwent both liver stiffness measurement by 2D SWE and liver biopsy for hepatic fibrosis grading, were enrolled. The diagnostic performances of the CV and the IQR/M were analyzed using receiver operating characteristic curves with areas under the curves (AUCs) and were compared by Fisher's Z test, based on matching the cutoff points in an interactive dot diagram. All P values less than 0.05 were considered significant.
Results
When using the cutoff value IQR/M of 0.21, the matched cutoff point of CV was 20%. When a cutoff value of CV of 20% was used, the diagnostic performance for advanced hepatic fibrosis ( ≥ F3 grade) with CV of less than 20% was better than that in the group with CV greater than or equal to 20% (AUC 0.967 versus 0.786, z statistic = 2.23, P = .025), whereas when the matched cutoff value IQR/M of 0.21 showed no difference (AUC 0.918 versus 0.927, z statistic = −0.178, P = .859).
Conclusions
The validity of liver stiffness measurements made by 2D SWE for assessing advanced hepatic fibrosis may be judged using CVs, and when the CV is less than 20% it can be considered “more reliable” than using IQR/M of less than 0.21.
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