The Clinical Characteristics and Prognosis of Crohn's Disease in Korean Patients Showing Proximal Small Bowel Involvement: Results from the CONNECT Studyopen access
- Authors
- Kim, One Zoong; Han, Dong Soo; Park, Chan Hyuk; Eun, Chang Soo; Kim, You Sun; Kim, Young-Ho; Cheon, Jae Hee; Ye, Byong Duk; Kim, Joo Sung
- Issue Date
- Jan-2018
- Publisher
- EDITORIAL OFFICE GUT & LIVER
- Keywords
- Crohn disease; Proximal small bowel; Jejunum; Prognosis; General surgery
- Citation
- GUT AND LIVER, v.12, no.1, pp.67 - 72
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- GUT AND LIVER
- Volume
- 12
- Number
- 1
- Start Page
- 67
- End Page
- 72
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3181
- DOI
- 10.5009/gnl16500
- ISSN
- 1976-2283
- Abstract
- Background/Aims: We aimed to evaluate the clinical characteristics and prognosis of Crohn's disease (CD) in patients who showed proximal small bowel involvement using a nationwide Korean CD cohort.
Methods: We reviewed the data from a cohort of patients diagnosed with CD. The clinical outcomes of patients were evaluated according to the presence of proximal small bowel involvement.
Results: Among 1,329 patients with CD for whom complete disease location data were available, 222 patients (16.7%) showed involvement of the proximal small bowel. Compared to patients without proximal small bowel involvement, those with small bowel involvement were more likely to display stricturing behavior (19.8% vs 12.7%, p=0.020). The surgery-free survival of patients who showed proximal small bowel involvement was inferior to that of patients without proximal small bowel involvement (10-year surgery-free survival: 58.4% vs 67.7%, respectively, p<0.001). Additionally, upper gastrointestinal involvement was more common in patients with proximal small bowel involvement than in those without involvement (odds ratio, 1.643; 95% confidence interval, 1.008 to 2.677).
Conclusions: Proximal small bowel involvement is a poor prognostic factor for the surgery-free survival of Korean patients with CD. Proximal small bowel involvement should be evaluated in patients with CD for predicting long-term clinical outcomes.
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