Two arms hydrophilic photosensitizer conjugates with vitamin B for cancer-selective photodynamic therapyopen access
- Authors
- Kim, Kyoung Sub; Song, Cheol Jun; Jaung, Jae Yun; Na, Kun
- Issue Date
- Apr-2017
- Publisher
- WILEY
- Keywords
- cancer selective; photodynamic therapy; hydrophilic photosensitizer; vitamin B; theranostic
- Citation
- POLYMERS FOR ADVANCED TECHNOLOGIES, v.28, no.4, pp 443 - 448
- Pages
- 6
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- POLYMERS FOR ADVANCED TECHNOLOGIES
- Volume
- 28
- Number
- 4
- Start Page
- 443
- End Page
- 448
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3213
- DOI
- 10.1002/pat.3904
- ISSN
- 1042-7147
1099-1581
- Abstract
- Cancer-selective internalization has a great potential for reducing the side effect of photodynamic therapy. Recently, various cancer-targeted delivery carriers have provided enhanced cancer targeting efficiency. Despite significant advancements in cancer-targeted carriers, side effects are still present because of non-selective cellular uptake that occurs in the heterogeneous cancer environment. In this paper, we designed two types of cancer-selectable two arm hydrophilic photosensitizer (CTAHP2K and CTAHP4K) with silicon-tetrapyrazinoporphyrazines (ST), polyethylene glycol and the cancer-specific ligand for cancer-selective theranostics. The synthesized CTAHP4K exhibits a folate receptor-mediated cancer-selective cellular uptake and induces cancer-selective death. The folate receptor-mediated cancer-selective internalization of CTAHP4K was confirmed by competitive interaction with vitamin B in MDA-MB-231 human breast carcinoma. The cancer-selective cytotoxicity of CTAHP4K was confirmed using a 670-nm laser to irradiate Chang Liver cells and MDA-MB-231 cells.
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