Cardiovascular and Gastrointestinal Effects of Etoricoxib in the Treatment of Osteoarthritis: A Systematic Review and Network Meta-analysisCardiovascular and Gastrointestinal Effects of Etoricoxib in the Treatment of Osteoarthritis: A Systematic Review and Network Meta-analysis
- Other Titles
- Cardiovascular and Gastrointestinal Effects of Etoricoxib in the Treatment of Osteoarthritis: A Systematic Review and Network Meta-analysis
- Authors
- 김담; 조수경; 남승완; 권혁희; 정선영; 전찬홍; 임슬기; 김달호; 장은진; 성윤경
- Issue Date
- Oct-2017
- Publisher
- 대한류마티스학회
- Keywords
- Anti-inflammatory agents; non-steroidal; Etoricoxib; Osteoarthritis; Safety
- Citation
- 대한류마티스학회지, v.24, no.5, pp.293 - 302
- Indexed
- KCI
- Journal Title
- 대한류마티스학회지
- Volume
- 24
- Number
- 5
- Start Page
- 293
- End Page
- 302
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3476
- DOI
- 10.4078/JRD.2017.24.5.293
- ISSN
- 2093-940X
- Abstract
- Objective.
To estimate the cardiovascular (CV) and gastrointestinal (GI) risks of etoricoxib in the treatment of osteoarthritis (OA) compared to a placebo and other non-steroidal anti-inflammatory drugs (NSAIDs).
Methods.
A systematic review of randomized, controlled trials (RCTs) of etoricoxib were performed. Bayesian network meta-analysis was used over a duration of 12 weeks. The incidence of CV and GI events for a duration ≥26 weeks were also tabulated and presented using descriptive statistics.
Results.
From this search, 10 studies were identified. Of these, 6 and 5 RCTs that measured the CV and GI events at 12 weeks were included in meta-analysis. They showed that etoricoxib did not increase the CV events compared to the placebo or NSAIDs during the 12 week period (odds ratio [OR]=0.59 compared to celecoxib, OR=0.89 with ibuprofen, OR=0.70 with placebo, and OR=2.16 with naproxen). The risk of GI events was comparable to that of most comparators, with the exception of naproxen, which had a significantly lower risk of GI events (OR=0.18) during the 12 week period. For a duration ≥26 weeks, the incidence of CV and GI events with etoricoxib increased with increasing duration.
Conclusion.
Etoricoxib is an alternative short-term treatment option for OA, showing comparable CV and GI complications to other NSAIDs. Nevertheless, further studies will be needed to elucidate the long-term safety of etoricoxib in the treatment of OA.
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