Breast cancer in systemic lupusopen access
- Authors
- Bernatsky, Sasha R.; Ramsey Goldman, Rosalind; Pétri, Michelle A.; Urowitz, Murray B.; Gladman, Dafna D.; Fortin, Paul R.; Ginzler, Ellen M.; Romero-Diaz, J.; Peschken, Christine A.; Jacobsen, Sóren Dyring; Hanly, John G.; Gordon, Caroline P.; Nived, Ola; Yelin, Edward H.; Isenberg, David A.; Rahman, A. T.M.Anishur; Bae, Sang-cheol; Joseph, Lawrence; Witte, Torsten; Ruiz-Irastorza, G.; Aranow, Cynthia B.; Kamen, Diane L.; Sturfeldt, Gunnar; Foulkes, William D.; Hansen, James E.; St.-Pierre, Yvan; Raymer, P. Chrétien; Tessier-Cloutier, Basile; Clarke, Ann Elaine
- Issue Date
- Mar-2017
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- Breast cancer; systemic lupus erythematosus
- Citation
- LUPUS, v.26, no.3, pp.311 - 315
- Indexed
- SCIE
SCOPUS
- Journal Title
- LUPUS
- Volume
- 26
- Number
- 3
- Start Page
- 311
- End Page
- 315
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3571
- DOI
- 10.1177/0961203316664595
- ISSN
- 0961-2033
- Abstract
- Objective
There is a decreased breast cancer risk in systemic lupus erythematosus (SLE) versus the general population. We assessed a large sample of SLE patients, evaluating demographic and clinical characteristics and breast cancer risk.
Methods
We performed case-cohort analyses within a multi-center international SLE sample. We calculated the breast cancer hazard ratio (HR) in female SLE patients, relative to demographics, reproductive history, family history of breast cancer, and time-dependent measures of anti-dsDNA positivity, cumulative disease activity, and drugs, adjusted for SLE duration.
Results
There were 86 SLE breast cancers and 4498 female SLE cancer-free controls. Patients were followed on average for 7.6 years. Versus controls, SLE breast cancer cases tended to be white and older. Breast cancer cases were similar to controls regarding anti-dsDNA positivity, disease activity, and most drug exposures over time. In univariate and multivariate models, the principal factor associated with breast cancers was older age at cohort entry.
Conclusions
There was little evidence that breast cancer risk in this SLE sample was strongly driven by any of the clinical factors that we studied. Further search for factors that determine the lower risk of breast cancer in SLE may be warranted.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3571)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.