항결핵제유발 간 손상에서 인터루킨-10과 전환성장인자-베타1 유전다형태
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Sodam | - |
dc.contributor.author | Kim, Sang-Hoon | - |
dc.contributor.author | Sohn, Jang Won | - |
dc.contributor.author | Yoon, Ho Joo | - |
dc.contributor.author | Shin, Dong Ho | - |
dc.contributor.author | Jee, Young-Koo | - |
dc.contributor.author | Kim, Sang-Heon | - |
dc.date.accessioned | 2021-07-30T05:12:32Z | - |
dc.date.available | 2021-07-30T05:12:32Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 2288-0402 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3614 | - |
dc.description.abstract | Purpose: Drug-induced liver injury is one of the serious adverse reactions resulting in severe morbidity and discontinuation of medications. Previously, IL- 10 gene polymorphism has been reported to be associated with diclofenac- induced hepatitis. In this study, we aimed to investigate the associations between genetic polymorphisms of immune- regulating cytokines (IL- 10 and TGF- a1) with antituberculosis drugs (ATD)- induced liver injury. Methods: We enrolled 80 patients with ATD- induced liver injury and 238 ATD- tolerant controls. Two single nucleotide polymorphisms (SNP) of IL- 10 (- 1082A> G, rs1800896; - 819T> C, rs1800871) and one promoter SNP of TGF- beta 1 gene (- 509C> T, rs1800469) were genotyped in both groups. Genotype frequencies of these SNPs were compared between case and control groups. Results: In 2 promoter SNPs of IL- 10 gene, there was no significant difference of genotype frequencies between patients with ATDinduced liver injury and controls. In addition, the genotype frequency of TGF- beta 1 - 509C> T SNP in ATD- induced liver injury patients were not different from those of controls. Conclusion: In conclusion, there was no significant association between IL- 10 and TGF- beta 1 gene polymorphisms and ATD- induced liver injury. These findings suggest that IL- 10 and TGF- beta 1 do not play important role in the development of ATD- induced liver injury. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY | - |
dc.title | 항결핵제유발 간 손상에서 인터루킨-10과 전환성장인자-베타1 유전다형태 | - |
dc.title.alternative | Genetic polymorphisms of interleukin-10 and transforming growth factor-beta 1 and antituberculosis drugs-induced liver injury | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sohn, Jang Won | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Joo | - |
dc.contributor.affiliatedAuthor | Kim, Sang-Heon | - |
dc.identifier.doi | 10.4168/aard.2017.5.1.41 | - |
dc.identifier.bibliographicCitation | ALLERGY ASTHMA & RESPIRATORY DISEASE, v.5, no.1, pp.41 - 46 | - |
dc.relation.isPartOf | ALLERGY ASTHMA & RESPIRATORY DISEASE | - |
dc.citation.title | ALLERGY ASTHMA & RESPIRATORY DISEASE | - |
dc.citation.volume | 5 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 41 | - |
dc.citation.endPage | 46 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002193495 | - |
dc.description.journalClass | 2 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.subject.keywordPlus | GROWTH-FACTOR-BETA | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | INDUCED HEPATOTOXICITY | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | STATEMENT | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | IL-10 | - |
dc.subject.keywordAuthor | Antitubercular agents | - |
dc.subject.keywordAuthor | Drug-induced liver injury | - |
dc.subject.keywordAuthor | Interleukin-10 | - |
dc.subject.keywordAuthor | Transforming growth factor beta1 | - |
dc.subject.keywordAuthor | Genetic polymorphism | - |
dc.identifier.url | https://aard.or.kr/DOIx.php?id=10.4168/aard.2017.5.1.41 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.