항결핵제유발 간 손상에서 인터루킨-10과 전환성장인자-베타1 유전다형태

Abstract

Purpose: Drug-induced liver injury is one of the serious adverse reactions resulting in severe morbidity and discontinuation of medications. Previously, IL- 10 gene polymorphism has been reported to be associated with diclofenac- induced hepatitis. In this study, we aimed to investigate the associations between genetic polymorphisms of immune- regulating cytokines (IL- 10 and TGF- a1) with antituberculosis drugs (ATD)- induced liver injury.

Methods: We enrolled 80 patients with ATD- induced liver injury and 238 ATD- tolerant controls. Two single nucleotide polymorphisms (SNP) of IL- 10 (- 1082A> G, rs1800896; - 819T> C, rs1800871) and one promoter SNP of TGF- beta 1 gene (- 509C> T, rs1800469) were genotyped in both groups. Genotype frequencies of these SNPs were compared between case and control groups.

Results: In 2 promoter SNPs of IL- 10 gene, there was no significant difference of genotype frequencies between patients with ATDinduced liver injury and controls. In addition, the genotype frequency of TGF- beta 1 - 509C> T SNP in ATD- induced liver injury patients were not different from those of controls.

Conclusion: In conclusion, there was no significant association between IL- 10 and TGF- beta 1 gene polymorphisms and ATD- induced liver injury. These findings suggest that IL- 10 and TGF- beta 1 do not play important role in the development of ATD- induced liver injury.