항결핵제유발 간 손상에서 인터루킨-10과 전환성장인자-베타1 유전다형태open accessGenetic polymorphisms of interleukin-10 and transforming growth factor-beta 1 and antituberculosis drugs-induced liver injury
- Other Titles
- Genetic polymorphisms of interleukin-10 and transforming growth factor-beta 1 and antituberculosis drugs-induced liver injury
- Authors
- Jung, Sodam; Kim, Sang-Hoon; Sohn, Jang Won; Yoon, Ho Joo; Shin, Dong Ho; Jee, Young-Koo; Kim, Sang-Heon
- Issue Date
- Jan-2017
- Publisher
- KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY
- Keywords
- Antitubercular agents; Drug-induced liver injury; Interleukin-10; Transforming growth factor beta1; Genetic polymorphism
- Citation
- ALLERGY ASTHMA & RESPIRATORY DISEASE, v.5, no.1, pp.41 - 46
- Indexed
- KCI
- Journal Title
- ALLERGY ASTHMA & RESPIRATORY DISEASE
- Volume
- 5
- Number
- 1
- Start Page
- 41
- End Page
- 46
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3614
- DOI
- 10.4168/aard.2017.5.1.41
- ISSN
- 2288-0402
- Abstract
- Purpose: Drug-induced liver injury is one of the serious adverse reactions resulting in severe morbidity and discontinuation of medications. Previously, IL- 10 gene polymorphism has been reported to be associated with diclofenac- induced hepatitis. In this study, we aimed to investigate the associations between genetic polymorphisms of immune- regulating cytokines (IL- 10 and TGF- a1) with antituberculosis drugs (ATD)- induced liver injury.
Methods: We enrolled 80 patients with ATD- induced liver injury and 238 ATD- tolerant controls. Two single nucleotide polymorphisms (SNP) of IL- 10 (- 1082A> G, rs1800896; - 819T> C, rs1800871) and one promoter SNP of TGF- beta 1 gene (- 509C> T, rs1800469) were genotyped in both groups. Genotype frequencies of these SNPs were compared between case and control groups.
Results: In 2 promoter SNPs of IL- 10 gene, there was no significant difference of genotype frequencies between patients with ATDinduced liver injury and controls. In addition, the genotype frequency of TGF- beta 1 - 509C> T SNP in ATD- induced liver injury patients were not different from those of controls.
Conclusion: In conclusion, there was no significant association between IL- 10 and TGF- beta 1 gene polymorphisms and ATD- induced liver injury. These findings suggest that IL- 10 and TGF- beta 1 do not play important role in the development of ATD- induced liver injury.
- Files in This Item
-
- Appears in
Collections - 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3614)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.