Association between circulating transforming growth factor-beta 1 level and polymorphisms in systemic lupus erythematosus and rheumatoid arthritis: A meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Y. H. | - |
dc.contributor.author | Bae, Sang Cheol | - |
dc.date.accessioned | 2021-07-30T05:12:34Z | - |
dc.date.available | 2021-07-30T05:12:34Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 0145-5680 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3618 | - |
dc.description.abstract | This study systemically reviewed evidence regarding the relationship between circulating blood transforming growth factor-beta 1 (TGF-beta 1) levels and systemic lupus erythematous (SLE) and rheumatoid arthritis (RA), and associations between TGF-beta 1 polymorphisms and susceptibility to SLE and RA. We conducted a meta-analysis on the serum/plasma TGF-beta 1 levels in SLE and RA patients and healthy controls, and the associations between TGF-beta 1 + 869 T/C, + 915 C/G, and -509 T/C polymorphisms and SLE or RA risk. Twenty-eight studies were considered in this meta-analysis. Circulating TGF-beta 1 levels were significantly lower in the SLE group than in controls (SMD = -1.164, 95% CI = -2.257 --0.070, P = 0.037). Serum/plasma TGF-beta 1 levels were not significantly different between RA and control groups (SMD = 0.699, 95% CI = -0.379 -1.717, p = 0.211). No association between TGF-beta 1 + 869 T/C polymorphism and SLE was found. However, meta-analysis showed an association between the TGF-beta 1 + 869 T allele and RA in all subjects (OR = 1.282, 95% CI = 1.118-1.470, P = 3.8 x 10⁻⁴). Analysis after stratification by ethnicity indicated that the T allele was significantly associated with RA in Asians and Arabs (OR = 1.429, 95% CI = 1.179-1.733, P = 2.9 x 10⁻⁴; OR = 1.352, 95% CI = 1.097-1.668, P = 0.005), but not Europeans. However, no association was found between TGF-beta 1 + 915 G/C or -509 C/T polymorphisms and RA or SLE. Meta-analysis revealed a significantly lower circulating TGF-beta 1 level in SLE patients, and a significant association between TGF-beta 1 + 869 T/C polymorphism and RA development. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | C M B ASSOC | - |
dc.title | Association between circulating transforming growth factor-beta 1 level and polymorphisms in systemic lupus erythematosus and rheumatoid arthritis: A meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bae, Sang Cheol | - |
dc.identifier.doi | 10.14715/cmb/2017.63.1.11 | - |
dc.identifier.scopusid | 2-s2.0-85015353806 | - |
dc.identifier.wosid | 000397291600011 | - |
dc.identifier.bibliographicCitation | CELLULAR AND MOLECULAR BIOLOGY, v.63, no.1, pp.53 - 59 | - |
dc.relation.isPartOf | CELLULAR AND MOLECULAR BIOLOGY | - |
dc.citation.title | CELLULAR AND MOLECULAR BIOLOGY | - |
dc.citation.volume | 63 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 53 | - |
dc.citation.endPage | 59 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | GROWTH-FACTOR-BETA | - |
dc.subject.keywordPlus | CYTOKINE GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | SERUM-LEVELS | - |
dc.subject.keywordPlus | SJOGRENS-SYNDROME | - |
dc.subject.keywordPlus | TGF-BETA-1 | - |
dc.subject.keywordPlus | INTERLEUKIN-10 | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | TRANSFORMING-GROWTH-FACTOR-BETA-1 | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordAuthor | TGF-beta 1 | - |
dc.subject.keywordAuthor | level | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | SLE | - |
dc.subject.keywordAuthor | RA | - |
dc.identifier.url | http://www.cellmolbiol.org/index.php/CMB/article/view/1140 | - |
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