Association between circulating transforming growth factor-beta 1 level and polymorphisms in systemic lupus erythematosus and rheumatoid arthritis: A meta-analysisopen access
- Authors
- Lee, Y. H.; Bae, Sang Cheol
- Issue Date
- Jan-2017
- Publisher
- C M B ASSOC
- Keywords
- TGF-beta 1; level; Polymorphism; SLE; RA
- Citation
- CELLULAR AND MOLECULAR BIOLOGY, v.63, no.1, pp.53 - 59
- Indexed
- SCIE
SCOPUS
- Journal Title
- CELLULAR AND MOLECULAR BIOLOGY
- Volume
- 63
- Number
- 1
- Start Page
- 53
- End Page
- 59
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3618
- DOI
- 10.14715/cmb/2017.63.1.11
- ISSN
- 0145-5680
- Abstract
- This study systemically reviewed evidence regarding the relationship between circulating blood transforming growth factor-beta 1 (TGF-beta 1) levels and systemic lupus erythematous (SLE) and rheumatoid arthritis (RA), and associations between TGF-beta 1 polymorphisms and susceptibility to SLE and RA. We conducted a meta-analysis on the serum/plasma TGF-beta 1 levels in SLE and RA patients and healthy controls, and the associations between TGF-beta 1 + 869 T/C, + 915 C/G, and -509 T/C polymorphisms and SLE or RA risk. Twenty-eight studies were considered in this meta-analysis. Circulating TGF-beta 1 levels were significantly lower in the SLE group than in controls (SMD = -1.164, 95% CI = -2.257 --0.070, P = 0.037). Serum/plasma TGF-beta 1 levels were not significantly different between RA and control groups (SMD = 0.699, 95% CI = -0.379 -1.717, p = 0.211). No association between TGF-beta 1 + 869 T/C polymorphism and SLE was found. However, meta-analysis showed an association between the TGF-beta 1 + 869 T allele and RA in all subjects (OR = 1.282, 95% CI = 1.118-1.470, P = 3.8 x 10⁻⁴). Analysis after stratification by ethnicity indicated that the T allele was significantly associated with RA in Asians and Arabs (OR = 1.429, 95% CI = 1.179-1.733, P = 2.9 x 10⁻⁴; OR = 1.352, 95% CI = 1.097-1.668, P = 0.005), but not Europeans. However, no association was found between TGF-beta 1 + 915 G/C or -509 C/T polymorphisms and RA or SLE. Meta-analysis revealed a significantly lower circulating TGF-beta 1 level in SLE patients, and a significant association between TGF-beta 1 + 869 T/C polymorphism and RA development.
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