Recent challenges and advances in genetically-engineered cell therapyopen access
- Authors
- Yong, Seok-Beom; Chung, Jee Young; Song, Yoonsung; Kim, Yong-Hee
- Issue Date
- Dec-2017
- Publisher
- Springer Netherlands
- Keywords
- Cell therapy; Gene engineering; Gene-modified cell therapy; Immune cell therapy; Stem cell therapy
- Citation
- Journal of Pharmaceutical Investigation, v.48, no.2, pp.199 - 208
- Indexed
- SCOPUS
KCI
- Journal Title
- Journal of Pharmaceutical Investigation
- Volume
- 48
- Number
- 2
- Start Page
- 199
- End Page
- 208
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3954
- DOI
- 10.1007/s40005-017-0381-1
- ISSN
- 2093-5552
- Abstract
- Cells naturally sense and actively response to their environment. Cell-therapy has long been studied and shown therapeutic effects in various diseases. However, several hurdles should be overcome to improve cell-based therapy. Gene delivery-mediated cellular modification has shown improvement of cell function by obstacle gene silencing and therapeutic gene expression. Especially, CRISPR/Cas9-mediated genome editing is a very promising method for gene modification. In this review, we describe the recent advances in genetic modification for cell therapy. Stem cells are still promising source of cell therapy due to their self-renewal character and differentiation potential. Immune cells regulate the inflammatory response and immunization, which inspired various cell therapy using immune-regulatory cells. Conclusively, we emphasize the need to develop gene-modification-based cell therapy as potent future treatment.
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