Identification and Functional Characterization of Anti-metastasis and Anti-angiogenic Activities of Triethylene Glycol Derivatives
- Authors
- Oh, Eonju; Garg, Sukant; Liu, Ye; Afzal, Sajal; Gao, Ran; Yun, Chae-Ok; Kaul, Sunil C.; Wadhwa, Renu
- Issue Date
- Nov-2018
- Publisher
- FRONTIERS MEDIA SA
- Keywords
- Ashwagandha; TEG; TEG-derivatives; cell migration; invasion; metastasis; therapy
- Citation
- FRONTIERS IN ONCOLOGY, v.8
- Indexed
- SCIE
SCOPUS
- Journal Title
- FRONTIERS IN ONCOLOGY
- Volume
- 8
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4662
- DOI
- 10.3389/fonc.2018.00552
- ISSN
- 2234-943X
- Abstract
- We had previously reported anticancer activity in the water extract (WEX) of Ashwagandha leaves, and identified Triethylene glycol (TEG) as an active tumor suppressor component. In this study, we investigated anti-migratory and anti-angiogenesis activities of WEX and TEG. We conducted in vitro and in vivo experiments using TEG, and its two derivatives, Triethyleneglycol dimethacrylate (TD-10), and Tetraethyleneglycol dimethacrylate (TD-11). The data revealed strong anticancer and anti-metastasis potentials in the derivatives. Non-toxic, anti-migratory doses of the derivatives showed inhibition of canonical Wnt/beta-catenin axis and consequent downregulation of EMT-signaling proteins (Vimentin, MMPs and VEGF). These results endorse that the TD-10 and TD-11 have potential to safely put a check on the aggressiveness of the metastatic cells and therefore represent promising candidates for the treatment of metastatic cancers.
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