Gene Expression Profile in Patients with Axial Spondyloarthritis: Meta-analysis of Publicly Accessible Microarray Datasetsopen access
- Authors
- 박로빈; 김태환; 지종대
- Issue Date
- Dec-2016
- Publisher
- 대한류마티스학회
- Keywords
- Axial spondyloarthritis; Ankylosing spondylitis; Microarray; Network analysis
- Citation
- 대한류마티스학회지, v.23, no.6, pp.363 - 372
- Indexed
- KCI
- Journal Title
- 대한류마티스학회지
- Volume
- 23
- Number
- 6
- Start Page
- 363
- End Page
- 372
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4862
- DOI
- 10.4078/jrd.2016.23.6.363
- ISSN
- 2093-940X
- Abstract
- Objective.
To identify a gene expression signature in axial spondyloarthritis/ankylosing spondylitis (SpA/AS) and genomic pathways likely to be involved in pathogenesis of SpA/AS patients.
Methods.
Four publicly accessible microarray studies from SpA/AS patients were integrated, and a transcriptomic and network-based meta-analysis was performed. This meta-analysis was compared with a published microarray study in whole blood of AS patients.
Results.
According to our meta-analysis, 1,798 genes were differentially expressed in the whole blood of SpA/AS patients compared to healthy controls, while 674 genes were differentially expressed in the synovium of SpA/AS patients compared to healthy controls. When the whole blood meta-analysis data was compared with a published microarray study that also analyzed whole blood in SpA/AS patients, pathways involved in Toll-like receptor signaling, osteoclast differentiation, T cell receptor signaling and janus kinase–signal transducer and activator of transcription (Jak-STAT) signaling were often enriched in SpA/AS. On the other hand, eomesodermin, RUNX3, and interleukin- 7 receptor (IL7R) were usually decreased in SpA/AS patients, suggesting that deficiency of these genes contributes to increased IL-17 production in AS.
Conclusion.
Several common enrichment pathways including Toll-like receptor signaling pathway, osteoclast differentiation, T cell receptor signaling pathway and Jak-STAT signaling pathway were identified in the differentially expressed genes of whole blood and synovium from SpA/AS patients, suggesting that these pathways are involved in the pathogenesis of SpA/AS. (J Rheum Dis 2016;23:363-372)
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4862)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.