Efficacy of tocilizumab therapy in Korean patients with adult-onset Still's disease: a multicentre retrospective study of 22 cases
- Authors
- Song, Seung Taek; Kim, Jin Ju; Lee, Seung; Kim, Hyoun-Ah; Lee, Eun Young; Shin, Ki Chul; Lee, Joo Hyun; Lees, Kwang-Hoon; Choi, Sang Tae; Cha, Hoon-Suk; Yoo, Dae Hyun
- Issue Date
- Nov-2016
- Publisher
- CLINICAL & EXPER RHEUMATOLOGY
- Keywords
- adult-onset Still' s disease; refractory; biological agents; tocilizumab; interleukin
- Citation
- CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v.34, no.6, pp.S64 - S71
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
- Volume
- 34
- Number
- 6
- Start Page
- S64
- End Page
- S71
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4909
- ISSN
- 0392-856X
- Abstract
- Objective. To evaluate the efficacy of tocilizumab (TCZ), a monoclonal antibody against the interleukin (IL)-6 receptor, for refractory adult-onset Still's disease (AOSD) in the Korean population. Methods. This retrospective study included 22 Korean patients with refractory AOSD who were given TCZ at one of seven university hospital-based clinics for rheumatic disease. Patients were subdivided into groups according to disease course: monocyclic, systemic polycyclic, and chronic articular. Modified Pouchot scores, including laboratory and clinical findings, were analysed at 6 months and 12 months. Results. TCZ was given at 4-8 mg/kg every 4-5 weeks (8 mglkg every 4-5 weeks in 18 patients, 6 mglkg every 4 weeks in 2, and 4 mglkg every 4 weeks in 2) for 7.5 months (median, IQR: 4.0-12 3). A good response (measured as a decrease of >2 in the modified Pouchot score) was achieved in 50.0% of patients (11 of 22) at 6 months and in 64.3% (9 of 14) at 12 months. The dose of corticosteroid dose was reduced from 11.5 mglday (median, IQR: 10.0-21.3) immediately before TCZ therapy to 7.5 mglday (median, IQR: 5.0-10.0, p=0.002) at 6 months and finally to 6.3 mg/day (median, IQR: 5.0-7.5, p=0.002) at 12 months. Only one patient discontinued TCZ treatment due to facial swelling accompanied by high blood pressure. In all others, adverse events subsided with delayed TCZ therapy, and TCZ therapy was continued successfully without problems. Conclusion. TCZ was effective for treating Korean AOSD patients who were refractory to conventional therapy or other anti-cytokine biologics, showing a corticosteroid-sparing effect and an acceptable tolerance profile.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4909)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.