Prevalence and possible causes of hypouricemia at a tertiary care hospitalopen access
- Authors
- Son, Chang-Nam; Kim, Ji-Min; Kim, Sang-Hyon; Cho, Soo-Kyung; Choi, Chan-Bum; Sung, Yoon-Kyoung; Kim, Tae-Hwan; Bae, Sang-Cheol; Yoo, Dae-Hyun; Jun, Jae-Bum
- Issue Date
- Sep-2016
- Publisher
- KOREAN ASSOC INTERNAL MEDICINE
- Keywords
- Hypouricemia; Uric acid
- Citation
- KOREAN JOURNAL OF INTERNAL MEDICINE, v.31, no.5, pp.971 - 976
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- KOREAN JOURNAL OF INTERNAL MEDICINE
- Volume
- 31
- Number
- 5
- Start Page
- 971
- End Page
- 976
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4968
- DOI
- 10.3904/kjim.2015.125
- ISSN
- 1226-3303
- Abstract
- Background/Aims: We aimed to investigate the prevalence and possible causes of hypouricemia in the Korean population and to compare our findings with published results of other populations.
Methods: We examined the serum uric acid levels of 30,757 subjects who had their uric acid values measured at least once during a 1-year period. All individuals with hypouricemia (serum uric acid < 2.0 mg/dL, n = 424) were reviewed with respect to medical drug history and concomitant diseases previously identified as being associated with hypouricemia.
Results: The prevalence of hypouricemia was 4.14% (299/7,223) among inpatients and 0.53% (125/23,534) among outpatients, for an overall prevalence of 1.39% (424/30,757). Possible causes associated with hypouricemia were found to be solid or hematologic malignancies (n = 86), diabetes mellitus (n = 56), and therapeutic drugs (n = 29). The medications were allopurinol (n = 11), angiotensin II receptor blockers (n = 10), salicylates (n = 6), febuxostat (n = 1), and warfarin (n = 1). In the remaining 226 individuals, the cause of hypouricemia was not identified.
Conclusions: Hypouricemia is relatively common in the Korean population compared to those of other countries. The possible causes associated with hypouricemia are related to underlying diseases and medications.
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